利伐沙班用法用量

Rivaroxaban usage and dosage: Rivaroxaban 10 mg can be taken with food or alone. Rivaroxaban 15 mg or 20 mg tablets should be taken with food.

1. To prevent venous thrombosis in adult patients undergoing elective hip or knee replacement surgery: the recommended dose is oral rivaroxaban 10 mg, once daily. If the wound has stopped bleeding, the first medication should be taken between 6 and 10 hours after surgery. For patients who have undergone major hip surgery, the recommended treatment course is 35 days. For patients who have undergone major knee surgery, the recommended treatment course is 12 days. If a missed dose occurs, the patient should take rivaroxaban immediately and continue to take the drug once a day the next day.

2. Treat DVT and reduce the risk of acute DVT recurrence and PE: The recommended initial treatment dose for acute DVT is 15 mg twice a day for the first three weeks, and the subsequent dose for maintenance treatment and reducing the risk of DVT recurrence and PE is 20 mg once a day. The dosage regimen of rivaroxaban tablets for DVT. After carefully evaluating the treatment benefits and bleeding risks, the duration of treatment should be determined according to individual circumstances. Short-term treatment (3 months) should be based on transient risk factors (eg, recent surgery, trauma, immobilization), and long-term treatment should be based on permanent risk factors or idiopathic DVT. There is insufficient experience with the use of rivaroxaban for more than 12 months for this indication.

If a missed dose occurs during 15 mg twice daily treatment (Days 1-21), patients should take rivaroxaban immediately to ensure 30 mg of rivaroxaban is taken daily. In this case, it may be necessary to take two 15 mg tablets at once. Thereafter, regular 15 mg twice daily dosing should be continued as recommended. If a missed dose occurs during 20 mg once-daily treatment (day 22 and beyond), the patient should begin rivaroxaban immediately and continue to receive once-daily dosing at the recommended dose thereafter. The dose should not be doubled in one day to make up for a missed dose.

3. For use in adult patients with non-valvular atrial fibrillation to reduce the risk of stroke and systemic embolism: the recommended dose is 20 mg once a day, which is also the maximum recommended dose. For patients with low body weight and advanced age (>75 years old), doctors can use 15 mg once a day as appropriate based on the patient's condition. In situations where the benefits of rivaroxaban in preventing stroke and systemic embolism outweigh the risks of bleeding, long-term treatment should be considered.

If a missed dose occurs, the patient should take rivaroxaban immediately and continue receiving the once-daily dose the next day. The dose should not be doubled in one day to make up for a missed dose. Discontinuation of anticoagulant therapy due to surgery or other interventional procedures. If anticoagulant therapy must be discontinued to reduce the risk of bleeding during surgery or other interventional procedures, rivaroxaban must be discontinued at least 242 hours before the intervention to reduce the risk of bleeding. Given the rapid onset of action of rivaroxaban, rivaroxaban should be reintroduced as soon as adequate hemostasis is determined after surgery or other interventional procedures. If oral medications cannot be taken during or after surgical intervention, consider administering a non-oral anticoagulant.

4. For patients who cannot swallow the whole tablet, crush the 10mg, 15mg or 20mg rivaroxaban tablet before taking the medicine, mix it with applesauce and take it immediately. Food should be eaten immediately after administration of crushed rivaroxaban 15 mg or 20 mg tablets. Administration via nasogastric tube (NG) or gastric feeding tube: After determining the position of the gastric tube in the stomach, 10 mg, 15 mg or 20 mg rivaroxaban tablets can also be crushed, mixed with 50 mL of water to form a suspension, and administered through a nasogastric tube or gastric feeding tube.