Does the non-hormonal drug Veozah's effectiveness in treating menopausal hot flashes vary from person to person?

The efficacy of the non-hormonal drug Veozah in treating menopausal hot flashes varies from person to person. The effect of the non-hormonal drug Veozah (filazonatant) on improving menopausal hot flashes varies from person to person. Different people have different reactions.

In most cases, Veozah has shown good therapeutic effects in treating menopausal hot flashes and can reduce the frequency and severity of menopausal hot flashes. However, everyone has different absorption and sensitivity to the drug, so the efficacy varies from person to person.

About Veozah

It is the first FDA-approved non-hormonal therapy for the treatment of moderate to severe vasomotor symptoms associated with menopause, commonly known as hot flashes or hot flashes. The drug works by blocking neurokinin B and restoring the balance between estrogen and neurokinin B, thereby reducing the frequency and intensity of hot flashes.

Veozah's effectiveness in treating menopausal hot flashes varies

Veozah (fezonatan) was evaluated in the first 12 weeks of a Phase III clinical trial, a randomized, placebo-controlled, double-blind study for the treatment of moderate to severe vasomotor symptoms associated with menopause.

Data from each trial also showed a statistically significant and clinically meaningful reduction in the frequency and severity of moderate to severe vasomotor symptoms (within 24 hours) in the Veozah 45 mg group compared to placebo at weeks 4 and 12, as well as a statistically significant and clinically meaningful reduction in the frequency and severity of hot flashes compared to the start of the study.

However, another clinical study showed that for vasomotor symptoms caused by menopause, the effect of Veozah (filazonetant) was not significantly different from placebo at the 4th and 12th weeks. The frequency and severity of vasomotor symptoms were not significantly reduced, which may be related to personal constitution, sensitivity to drugs and other factors.

Side effects and treatment measures of Veozah medication

Some symptoms may also occur during treatment, such as abdominal pain, diarrhea, insomnia, back pain, elevated liver transaminases, etc., which require targeted treatment based on different symptoms.

1. Abdominal pain: Patients should keep their abdomen warm to avoid aggravation of symptoms when the abdomen is cold. They can also take ibuprofen and other drugs as directed by the doctor to relieve pain.

2. Diarrhea: Avoid eating spicy, cold and spicy foods, such as peppers, ice cream, etc., to avoid irritating the gastrointestinal tract and aggravating diarrhea. Drink plenty of water to replenish moisture. If necessary, you can take antidiarrheal drugs as directed by your doctor. The most commonly used one is montmorillonite powder.

3. Insomnia: Avoid strenuous exercise before going to bed at night. You can soak your feet or drink a cup of hot milk, which will help you fall asleep. Avoid drinking coffee, wine and other drinks that can easily cause excitement.

4. Back pain: Pay attention to rest and avoid fatigue. Massage, hot compress, acupuncture, massage, ultrashort wave and other methods can be used to promote blood pressure circulation and relieve pain.

5. Elevated liver transaminase: Before starting treatment with Veozah, conduct a baseline blood test to evaluate liver function and damage. At 3 months, 6 months and 9 months after the start of treatment, if there are symptoms suggesting liver damage such as nausea, vomiting, yellowing of the skin or eyes, etc., timely examination of liver transaminase concentration is required.

Overall, the effectiveness of the non-hormonal drug Veozah in improving menopausal hot flashes varies from person to person. May be an effective option for patients who cannot receive hormone therapy. Blood tests need to be done before taking the medicine, and adverse reactions and contraindications need to be paid attention to. If you have any discomfort, please consult your doctor or pharmacist in time.

Recommended related articles: