Planep需要注意的事项有什么？

In 2002, Planep (alias: eplerenone, Inspra) was approved for clinical use by the State Food and Drug Administration. It has few adverse reactions and has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It is a good alternative to spironolactone. So what should you pay attention to when using Planep?

1. Planep cannot be combined with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes).

2. Non-steroidal anti-inflammatory drugs and lithium can affect the plasma concentration of Planep and affect the efficacy.

3. People with high serum potassium, type 2 diabetes patients with microalbuminuria, high serum creatinine levels, and muscle intoxication clearance <50 mL/min should not take Planep. Pregnant women, children, and those with hepatic and renal insufficiency should use with caution.

Side Effects of Planep:

The main side effects of Planep are: cough, diarrhea, abdominal pain, angina, myocardial infarction, proteinuria, headache, dizziness, fatigue, flu-like symptoms, etc.

Other side effects include: gynecomastia, abnormal vaginal bleeding; increased levels of serum potassium, triglycerides, cholesterol, alanine aminotransferase, γ-glutamyl transferase, creatinine, and uric acid, and decreased serum sodium levels.

Planep usage and dosage:

Serum potassium should be measured in all patients before treatment with Planep, during the first week after treatment initiation or dose adjustment, and within one month, and serum potassium should be evaluated periodically thereafter.

Dosage after acute myocardial infarction: The starting dose is 25 mg per day. Under conditions acceptable to the patient within 4 weeks, the titrated dose will be adjusted to 50 mg per day. The dose should also be adjusted according to the patient's potassium level.

Hypertension: 50 mg once daily, Planep can be used alone or in combination with other antihypertensive drugs. For patients with poor response, adjust to 50 mg twice a day. Higher doses are not recommended.