鲁索替尼乳膏在哪里能买到?

Purchase channels and prices of ruxolitinib cream

Ruxolitinib cream can be purchased in areas where it is already on the market.

Ruxolitinib cream has been launched in the United States in July 2022, but as of November 29, 2023, it has not been launched in mainland China. Patients cannot buy it in domestic hospital pharmacies, and no price has been announced. In other words, patients can buy it in the United States, or they can consult pharmacies in Hong Kong, China. There will be differences in different regions. But this requires traveling far away, and the place is unfamiliar, the language is not fluent, and there is no guarantee for purchasing medicine.

Patients who are inconvenient to travel can also get help from domestic professional overseas medical service organizations (such as Medical Companion Travel), and the drugs can be mailed to their homes. The prices currently known are as follows:

The price of ruxolitinib ointment (ruxolitinib cream) shipped by Yunda in Hong Kong, China, 30 mg The price is about 559$ per box;

The shipping price of ruxolitinib ointment in Bangladesh is about 480$ per box;

It is more cost-effective to get it through the help of domestic professional overseas medical service organizations (such as Medical Companion Travel), and it can guarantee the authenticity, but the price is not fixed due to various factors. It is recommended to consult customer service personnel for specific fees and acquisition procedures. It is recommended to purchase from formal and qualified channels to prevent being deceived.

About ruxolitinib cream

The therapeutic effect is relatively significant. It can inhibit the JAK signaling pathway, thereby reducing the autoimmune response in patients with vitiligo and promoting the regeneration and pigmentation of melanocytes. Studies have shown that the anti-inflammatory effects of ruxolitinib cream are primarily achieved by reducing the levels of inflammatory mediators in skin tissue. This anti-inflammatory effect helps reduce redness, itching, and pain in patients with atopic dermatitis and improves their quality of life.

Trial effects of ruxolitinib cream

In 2 phase II trials, treatment with ruxolitinib cream significantly improved the Vitiligo Area Score Index (VASI) compared with the control group. After 52 weeks, the 1.5% concentration applied twice daily was the most effective, with 58% of patients experiencing a 50% improvement in VASI, 52% experiencing a 75% improvement, and 33% experiencing a 90% improvement.

In both Phase III trials, more patients had at least a 75% improvement in facial VASI at 24 weeks (primary endpoint; Trial 1: 29.9%; Trial 2: 29.9%) compared with the control group (Trial 1: 7.5% [P < 0.0001]; Trial 2: 12.9% [P < 0.01]). Common adverse reactions were erythema, pruritus, and acne; all adverse reactions were mild.

Compared with traditional topical steroid hormones, calcineurin inhibitors, phototherapy and depigmenting agents, ruxolitinib cream has significant clinical efficacy, low bioavailability and few adverse reactions.

Trial Conclusions

Ruxolitinib cream is the first U.S. Food and Drug Administration-approved treatment for non-segmental vitiligo repigmentation. Clinicians should consider these advantages of ruxolitinib cream when recommending treatment, as traditional treatments may be longer and carry greater risks.

Indications of Ruxolitinib Cream

Ruxolitinib Cream is used to treat patients with mild to moderate atopic dermatitis (AD) over 12 years old, and patients with vitiligo over 12 years old. Patients applied a thin layer of ruxolitinib cream to the affected area twice daily, covering no more than 20% of the body surface area. The weekly dosage should not exceed 60g. This product is for topical use only and is not intended for ophthalmic, oral or intravaginal use.

Recommended hot articles:

References

Hwang JR, Driscoll MS. Review of Ruxolitinib for Treatment of Non-Segmental Vitiligo. Ann Pharmacother. 2023 Aug;57(8):948-955. doi: 10.1177/10600280221143748. Epub 2022 Dec 23. PMID: 36564903.