Is TPOXX effective in treating smallpox?

It has received "Orphan Drug" and "Fast Track" designations and "Priority Review" status, and is approved for the treatment of smallpox in adults and children weighing at least 13 kg. It is the first new drug approved to treat smallpox.

What is smallpox

Smallpox is a severe infectious disease caused by the variola virus in humans. People who recover from the disease can gain lifelong immunity. The most basic, effective and simplest prevention method is vaccination with cowpox (smallpox vaccine). Tpoxx is an inhibitor of the VP37 envelope protein of orthopoxvirus, which can effectively target the spread of smallpox virus in the body. The effectiveness of Tpoxx for smallpox is based on studies in animals, and safety was evaluated in 359 healthy volunteers who were not infected with smallpox.

Is TPOXX effective in treating smallpox?

TPOXX is an anti-smallpox virus drug that can be used for the treatment of symptomatic patients and the prophylaxis of infected but asymptomatic patients. It is in the late stage of research and development. Taking this drug can improve the safety of the smallpox vaccine. TPOXX is an export inhibitor that prevents orthopoxviruses from forming an enveloped virus in the extracellular form. It has been shown to have good post-exposure efficacy in rats, ground squirrels, prairie dogs, rabbits and various non-human primates infected by different orthopoxviruses, such as cowpox, rabbitpox, monkeypox and smallpox.

Clinical studies show that the drug appears to be safe and well tolerated. Animal experiments have shown that oral administration once a day can produce protective effects. Through extensive and repeated discussions with regulatory authorities, the approval path for this drug as a treatment for symptomatic patients has been clarified, and SIGA and its federal partners are executing relevant plans.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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