BioCryst公司的贝罗司他胶囊效果怎么样

Orladeyo is a plasma kallikrein inhibitor that binds to plasma kallikrein and inhibits its proteolytic activity. Currently, Orladeyo, berosostat capsules, has been approved by the U.S. Food and Drug Administration (FDA) for the prevention of hereditary angioedema (HAE) attacks in children and adult patients aged ≥12 years.

BioCryst Corporation is a biotechnology company. BioCryst designs, optimizes and develops small molecule drugs that block enzymes involved in disease pathogenesis. The company focuses on treating rare diseases. BioCryst uses X-ray scattering technology, molecular structure computer simulations and chemical techniques to focus on the three-dimensional molecular structure and active site characteristics of enzymes that control cell biology. How effective are BioCryst's berosostat capsules?

In the pivotal Phase 3 APeX-2 trial, BioCryst significantly reduced the number of hereditary angioedema HAE attacks over 24 weeks and continued through week 48. Patients who completed the 48-week trial experienced a significant reduction in the frequency of hereditary angioedema HAE attacks, from an average of 2.9 attacks/month at baseline to an average of 1 attack/month. Completion of another long-term open-label APeX-S study reduced the frequency of HAE attacks in patients with hereditary angioedema to an average of 0.8 episodes per month. It can be seen that the therapeutic effect of beroxostat capsule Orladeyo is very significant, and the successful development of this drug is good news for many patients.

However, patients are not allowed to use Orladeyo capsules for treatment without authorization. Orladeyo treatment will also produce certain side effects or adverse reactions. The most common adverse reactions include: abdominal pain/vomiting/diarrhea/back pain/gastroesophageal reflux disease, etc. And patients should note: Berosostat capsules Orladeyo should not be used to treat acute attacks of hereditary angioedema (HAE).

The above is the introduction about Orladeyo. If patients have other questions about Orladeyo (such as drug prices, purchase channels, etc.), they can consult the medical companion travel service.

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Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.