阿普斯特有几种规格?多少钱?

Apremilast is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor that regulates inflammatory responses by selectively inhibiting PDE4 and increasing intracellular cyclic adenosine monophosphate (cAMP) levels. Its specification selection and medication precautions are crucial to the therapeutic effect. This article will introduce in detail the relevant information of Apremilast from three aspects: drug specification classification, price comparison of each specification, and precautions for use.

Apremilast is available in several specifications

Apremilast is available in various specifications in the global market. The main difference lies in the content of a single pill and the quantity per box to meet the individual treatment needs of different patients.

Original drug specifications

Otezla, the original drug, is mainly available in 30mg specifications, with packaging formats of 30 capsules/box and 60 capsules/box. This standardized packaging design takes into account the integrity of the treatment cycle.

Generic drug specifications

Generic versions such as Glenmark in India also provide two mainstream specifications: 30mg×30 tablets and 30mg×60 tablets. Some manufacturers also produce 10 mg and 20 mg strengths for dosage adjustment.

Basis for strength selection

Doctors will decide which strength to use based on the severity of the patient's condition and tolerance. The 30 mg strength is used for maintenance treatment, and the small strength is used for the initial dose adjustment stage.

Patients should not adjust the specifications or dosage on their own during medication, and must strictly follow the doctor's instructions and use drugs of appropriate specifications.

How much does Apremilast cost in different specifications?

The price of Apremilast is directly related to the specifications, and is also affected by factors such as brand, origin, and purchasing channels.

Original drug price

Otezla, the original drug, is priced relatively high in the European and American markets, with a price of approximately US$4,700 per box of 30mg

Price of generic drugs

Apremilast produced by Glenmark Pharmaceuticals in India is available in two specifications. The price of 30mg×30 tablets is about US$22 per box, and the price of 30mg×60 tablets is about US$32 per box.

Factors affecting price

In addition to specifications, purchase quantity, exchange rate fluctuations and transportation costs will all affect the final price. You can usually get a certain discount for bulk purchases.

When selecting specifications and purchasing channels, patients should comprehensively consider the treatment effect and financial affordability, and make reasonable choices under the guidance of a doctor.

Precautions for Apremilast

Using Apremilast requires special attention to certain special risks and strict compliance with medication regulations.

Risk of allergic reactions

Clinical monitoring found that Apremilast may cause angioedema and allergic reactions. It is contraindicated for those who are allergic to the drug ingredients. If allergic symptoms occur during treatment, the drug should be discontinued immediately and seek medical attention.

Gastrointestinal Reactions

Diarrhea, nausea and vomiting are common adverse reactions, which mostly occur in the early stages of treatment. Patients over the age of 65 are at higher risk, and severe cases may require hospitalization.

Mental health effects

Drugs may aggravate depressive symptoms or trigger suicidal thoughts. Patients with a history of mental illness should use them with caution, and emotional changes should be closely monitored during treatment.

Weight changes

Some patients will experience unexplained weight loss. It is recommended to monitor weight regularly and evaluate whether to continue taking medication when significant weight loss occurs.

Drug Interactions

Combined use with potent CYP450 enzyme inducers will reduce the efficacy of the drug. During medication, rifampicin, phenobarbital and other drugs should be avoided.

Patients should understand these precautions in detail before using Apremilast, maintain close communication with their doctor during treatment, and report any abnormal reactions in a timely manner.