阿普斯特多少钱一盒？在哪里购买？

Apremilast is a new oral drug for the treatment of psoriasis and psoriatic arthritis. Its price and purchase channels are the focus of patients' attention. This article will provide patients with comprehensive medication guidance from three aspects: drug price trends, formal purchasing channels, and pharmacokinetic properties.

How much does a box of Apremilast cost?

The market prices vary significantly depending on versions, specifications and purchase channels. Understanding these differences can help patients make economically reasonable drug purchasing choices.

Original drug price

Otezla, an original drug produced by Celgene, has a higher retail price in the U.S. market. In European countries, patients’ out-of-pocket costs are usually significantly reduced after medical insurance reimbursement.

Prices of generic drugs in India

Apremilast produced by Glenmark Pharmaceuticals in India is available in two specifications. The price of 30mg×30 tablets is about US$22 per box, and the price of 30mg×60 tablets is about US$32 per box. Other Indian pharmaceutical companies such as Cipla have similar pricing.

Factors affecting price

Drug prices will change with exchange rate fluctuations, purchase quantities and transportation methods, and are for reference only. Buying in bulk often results in discounts, while purchasing through a health care provider may add to the cost of additional services.

When purchasing drugs, patients should ask for formal invoices and drug traceability information to ensure the quality and authenticity of the drugs purchased.

Where to buy Apremilast

The purchasing channels for Apremilast need to take into account both legality and convenience. Choosing a regular and reliable source is crucial to ensuring the quality of the drug.

Hospital Pharmacy

In countries where it has been approved for marketing, patients can purchase it directly at the hospital pharmacy with a prescription. In this way, the source of the medicine is reliable and they can get guidance from professional pharmacists.

Cross-border medical platform

Regular cross-border medical service agencies can assist patients to purchase generic versions of Apremilast from countries such as India. Such platforms usually provide direct mailing services for drugs and require patients to provide complete prescriptions and medical records.

International Pharmacy Official Website

Some international online pharmacies support Apremilast’s online shopping service. When choosing, you should confirm the pharmacy qualifications and verify the drug approval number and validity period information.

No matter which purchasing method you choose, you should avoid obtaining medicines through social platforms or personal channels to reduce the risk of medication.

Pharmacokinetics of Apremilast

Understanding the absorption, distribution, metabolism and excretion process of Apremilast in the body will help optimize the medication regimen and improve the therapeutic effect.

Absorption characteristics

Apremilast is rapidly absorbed after oral administration, with a median time to reach peak plasma concentration (Tmax) of 2.5 hours. A high-fat diet slightly delays absorption but does not affect overall bioavailability.

Distribution and Metabolism

The apparent distribution volume of the drug is 87L, and the plasma protein binding rate is approximately 68%. Mainly metabolized by CYP3A4, with a small amount metabolized by CYP1A2 and CYP2A6.

Excretion route

About 58% is excreted through the kidneys and 39% is excreted through the feces. The elimination half-life is approximately 6-9 hours, supporting a twice-daily dosing regimen.

By mastering these pharmacokinetic parameters, doctors can formulate dosage plans more rationally, and patients can better understand medication precautions.