阿普斯特治疗银屑病的效果怎么样？副作用大吗？

Apremilast, the first-in-class oral selective phosphodiesterase-4 (PDE-4) inhibitor, has been launched in the United States and Europe. It is the first oral drug approved for the treatment of psoriasis in the past 20 years. This drug is used for active psoriatic arthritis (PsA) and moderate to severe plaque psoriasis. Today we will learn more about the effect of treating psoriasis? Are there any serious side effects?

In 3 experimental studies, 1493 adult patients with PSA were randomized to receive placebo and Apremilast. The results showed that the proportion of ACR20 response patients in the 16th week of patients taking Apremilast was significantly higher than that in the placebo group. In the PSA-1 study, the Apremilast 30 mg, bid + DMARD group was 38%. In the PSA-2 study, the Apremilast group was 32%. In the study PSA-3, the Apremilast group was 41%, while in the placebo group PSA-1 Among them, 19% in the placebo + DMARDs group; 19% in the placebo group in Study PSA-2; and 18% in the placebo group in Study PSA-3. This shows that Apremilast is effective in treating PSA and the adverse effects are within acceptable limits. Apremilast has good selectivity, wide application, oral administration, convenient taking, low recurrence rate, good safety, single administration, precise efficacy, short half-life, and high tolerance. Trusted by many patients.

Although Apremilast is effective in treating psoriasis, it also has side effects. Upper respiratory tract infection, diarrhea, nausea, headaches, including tension headaches are common side effects of this drug in treating psoriasis. Common side effects in treating psoriatic arthritis are diarrhea, nausea, and headache. Patients should pay attention to their own reactions during medication, and if they have intolerance, contact their doctor promptly and adopt a new treatment plan.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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