埃索美拉唑和雷贝拉唑可以一起吃吗

(Nexium) is a type of PPI drug and is the S isomer of omeprazole. It reduces gastric acid secretion through a specific targeting mechanism. Clinically, it is mainly used for the treatment of gastroesophageal reflux disease, peptic ulcer, eradication of Helicobacter pylori and other related gastric acid suppression treatments. So many patients will ask whether esomeprazole (Nexium) and rabeprazole can be taken together?

Esomeprazole (Nexium) can reduce gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. Rabeprazole sodium enteric-coated tablets are proton pump inhibitors, which can inhibit excessive secretion of gastric acid and effectively repair ulcer mucosa. Taking esomeprazole (Nexium) and rabeprazole sodium enteric-coated tablets together does not effectively improve the efficacy of treating erosive reflux esophagitis, and taking similar drugs together will cause drug overlap, so the two drugs cannot be taken together.

In addition, the advice given to patients is to develop good eating habits, eat regularly, eat small meals frequently, avoid hard, cold, rough, and fiber-rich foods, and eat soft foods that are easy to digest.

When taking esomeprazole (Nexium), the tablets should be swallowed whole together with the liquid. They should not be chewed or crushed, otherwise the efficacy of the drug will be affected. For patients who cannot swallow, esomeprazole (Nexium) can be dissolved in carbonate-free water and given through a gastric tube.

Esomeprazole (Nexium) can keep the gastric pH >4 for longer. A study on the duration of gastric pH > 4 and the healing rate of reflux esophagitis showed that the longer the duration of pH > 4 within 24 hours, the greater the number of patients who healed after 8 weeks. After taking different drugs orally for 5 days, the duration of pH>4 in the stomach within 24 hours, from longest to shortest, is: esomeprazole (Nexium) 40 mg, omeprazole 40 mg, lansoprazole 30 mg, pantoprazole 40 mg and rabeprazole 20 mg. This shows that esomeprazole (Nexium) 40 mg has a stronger acid-suppressing effect than other proton pump inhibitors. Clinical trials have also fully confirmed the excellent pH control capabilities of esomeprazole (Nexium) 40mg. In general (Nexium) is very effective in treating early gastric cancer. Patients can choose to take it according to the doctor's advice.

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