埃索美拉唑的适应症

The indication for esomeprazole (Nexium) is that esomeprazole magnesium enteric-coated tablets are suitable for the treatment of gastroesophageal reflux disease (GERD) - erosive reflux esophagitis. Long-term maintenance treatment to prevent recurrence in patients with cured esophagitis. Symptom control of gastroesophageal reflux disease (GERD). Used in combination with appropriate antimicrobial therapy to eradicate Helicobacter pylori and - to heal duodenal ulcers associated with Helicobacter pylori infection - to prevent the recurrence of peptic ulcers associated with Helicobacter pylori infection.

Effects of esomeprazole (Nexium) on the pharmacokinetics of other drugs: For those drugs whose absorption process is affected by gastric acid, the absorption of these drugs can be increased or decreased during esomeprazole treatment due to the decrease in gastric acid. As with other oxyntic inhibitors or antacids, the absorption of ketozole and itraconazole will be reduced during esomeprazole treatment.

Esomeprazole (Nexium) inhibits CYP2C19, which is the main metabolizing enzyme of esomeprazole. Clinical evidence shows that taking certain proton pump inhibitors (which can compete with hepatic drug enzymes CYP2C9 and CYP2C19 and affect the metabolism of clopidogrel into active products) will reduce the efficacy of clopidogrel and increase patients' thrombotic adverse events. However, the inhibitory effects of various proton pump inhibitors are not the same. Omeprazole and lansoprazole have the most obvious inhibitory effects on clopidogrel, while pantoprazole and rabeprazole have weaker or less obvious effects. Clinical evidence shows that taking certain proton pump inhibitors (which can compete with hepatic drug enzymes CYP2C9 and CYP2C19 and affect the metabolism of clopidogrel into active products) will reduce the efficacy of clopidogrel and increase patients' thrombotic adverse events. However, the inhibitory effects of various proton pump inhibitors are not the same. Omeprazole and lansoprazole have the most obvious inhibitory effects on clopidogrel, while pantoprazole and rabeprazole have weaker or less obvious effects.