埃索美拉唑功效与作用

Esomeprazole (Nexium) efficacy and role: Esomeprazole is a proton pump inhibitor, currently renamed as esomeprazole, which acts on the H-K-ATPase of gastric mucosal parietal cells to inhibit gastric acid secretion, thus Improve acid-related diseases, such as gastroesophageal reflux disease, peptic ulcer (including gastric ulcer, duodenal ulcer), gastritis, and for patients with gastrointestinal bleeding, it can also increase the pH value in the stomach, promote coagulation and prevent the formation of blood scab from dissolving.

Esomeprazole (Nexium) is a new anti-pathogenic agent. The approved indication of esomeprazole (Nexium) is to prevent the recurrence of gastric ulcer and duodenal ulcer in patients receiving nonsteroidal anti-inflammatory drugs (NSAIDs). The approved indications of esomeprazole (Nexium) in Japan include reflux esophagitis and non-erosive reflux disease (NERD). On July 30, 2020, AstraZeneca announced that China’s National Medical Products Administration (NMPA) officially approved Nexium (esomeprazole sodium) injection for the prevention of stress ulcer bleeding in severe patients.

Esomeprazole (Nexium) is the S-isomer of omeprazole. It reduces gastric acid secretion through a specific rake action mechanism and is a specific inhibitor of proton pumps in parietal cells. Site and mechanism of action: Esomeprazole is a weak base, which is concentrated in the high-acid environment of parietal cell acid secretion microtubules and converted into an active form, thereby inhibiting H+/k+-ATP (proton pump) at this site, inhibiting both basic gastric acid secretion and stimulated gastric acid secretion.

According to Medical Travel, the price of the version of esomeprazole (Nexium) sold in Japan is about 1,900, and the price of the Indian version is about 500. For detailed drug price information, patients can consult the medical companion travel service.