吃阿瑞匹坦会引起哪些常见的副作用？

Aprepitant is the world's first approved NK-1 receptor antagonist antiemetic drug and the first pitant drug to be marketed in China. Its domestic trade name is Yimei. It is a drug used to prevent acute and delayed nausea and vomiting during initial and repeated treatment with highly emetogenic anti-tumor chemotherapy. So what are the common side effects caused by patients?

Patients may experience certain side effects during treatment with aprepitant, but the time and degree of these side effects vary from person to person. Each patient's constitution and disease progression are different, so the manifestations of side effects are also different for each patient. When patients experience certain side effects while taking aprepitant, they should consult the relevant doctor as soon as possible to change or replace the treatment plan. (1) The most common drug-related adverse reactions of taking aprepitant include: hiccups (4.6%), weakness/tiredness (2.9%), increased liver index ALT (2.8%), constipation (2.2%), headache (2.2%) and anorexia (2.0%). (2) Other adverse reactions include: redness, upper respiratory tract infection, tachycardia, weakness, pelvic pain, bone pain, pelvic pain, rash, hypokalemia, anxiety, etc. Bradycardia, disorientation, perforated duodenal ulcer, and Stevens-Johnson syndrome have also been reported.

The overall safety of aprepitant was evaluated in approximately 6,500 patients. The Domestic Clinical Trial of Highly Emetogenic Chemotherapy (HEC) conducted a randomized controlled clinical study in Chinese patients receiving highly emetogenic anti-tumor chemotherapy (HEC). In this study, 412 patients received aprepitant in the first cycle of chemotherapy, and 240 patients continued into the second phase of chemotherapy. The combined granisetron and dexamethasone (aprepitant treatment group) dosing regimen was generally well tolerated. The main clinical adverse events were mild to moderate.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.