舒必利和昂丹司琼片哪个效果好?

The atypical antipsychotic drug Sulpiride is a white or off-white crystalline powder. It is mainly used to treat diseases related to psychosis, schizophrenia and depression. Sulpiride is a benzamide drug with a strong antiemetic effect. It is clinically used to prevent or treat nausea and vomiting caused by chemotherapy drugs (such as cisplatin, doxorubicin, etc.) and radiotherapy. It is a highly selective 5-hydroxytryptamine (5-HT3) receptor antagonist. Today, let’s take a closer look at which one of Sulpiride and ondansetron tablets is more effective?

The bioavailability of ondansetron tablets is approximately 60% (higher in the elderly). When administered orally or intravenously, the in vivo situation of this product is roughly the same, and its elimination half-life is approximately 3 hours. Plasma protein binding rate is 75%. Sulpiride tablets can reach peak plasma concentration in 2 hours, and oral administration of this product takes 48 hours. The plasma half-life (t1/2) is 8 to 9 hours.

For the treatment of nausea and vomiting caused by chemotherapy and radiotherapy, ondansetron exerts its antiemetic effect by antagonizing the 5-HT receptors of peripheral neurons and central neurons. The mechanism of postoperative nausea and vomiting is not yet clear, but it may be caused by the common pathway of nausea and vomiting caused by cytotoxic substances. Ondansetron can inhibit opioid-induced nausea and vomiting. In terms of antiemetic effect, ondansetron tablets are more effective. However, patients should take medicine according to their own conditions, wait for the doctor to make a diagnosis before taking medicine, and do not use medicine casually. Only by prescribing the right medicine can the therapeutic effect be achieved.

The adverse reactions of the two drugs are also different, including fatigue, insomnia, early awakening, headache, irritability, loss of appetite, etc., resulting in patients experiencing adverse symptoms such as tachycardia, dry mouth, blurred vision, and difficulty urinating. These are all adverse reactions of Sulpiride. The main adverse reactions of ondansetron tablets are: abdominal discomfort, constipation, rash, dry mouth, headache, occasional bronchial asthma or allergic reactions, and transient asymptomatic increases in transaminases. However, these symptoms are mild and do not require treatment, but some serious reactions require consultation with a doctor to avoid delaying the condition.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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