昂丹司琼片用药注意事项

Ondansetron (trade name: Zofran) is a selective 5-HT3 receptor antagonist. Although its mechanism of action has not been fully characterized, ondansetron is not a dopamine receptor antagonist. 5-HT3 type serotonin receptors are present in the periphery of the vagus nerve terminals and in the center of the chemoreceptor triggering zone in the postcentral area. It is uncertain whether the antiemetic effects of ondansetron are mediated centrally, peripherally, or both. However, cytotoxic chemotherapy appears to be associated with the release of serotonin from enterochromaffin cells in the small intestine. In humans, urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion increases following cisplatin administration concurrent with the onset of vomiting. The released serotonin can stimulate vagal afferents through 5-HT3 receptors and trigger the gag reflex.

Let’s take a look at the precautions patients should take when taking ondansetron tablets. Patients may experience certain side effects during treatment with ondansetron tablets, but the time and degree of these side effects vary from person to person. If certain side effects occur, they should consult the relevant doctor as soon as possible to change or replace the treatment plan. Common adverse reactions of ondansetron include headache, fever in the head and upper abdomen, akathisia, diarrhea, rash, acute dystonic reaction, constipation, etc. It can occasionally cause transient elevation of aminotransferase. Bronchospasm, tachycardia, chest pain, hypokalemia, electrocardiogram changes, and grand mal epilepsy are rare. It is contraindicated in patients with gastrointestinal obstruction.

Patients should also pay attention to the following points while taking ondansetron: (1) For patients with renal damage, there is no need to adjust the dosage, frequency of medication, and route of administration. (2) For patients with liver function impairment, patients with moderate or severe liver function impairment, the daily dosage should not exceed 8 mg. (3) It should not be used after abdominal surgery to avoid masking symptoms of ileum or gastric dilation. (4) Suspend breastfeeding when using this product. (5) The U.S. FDA pregnancy drug safety classification is B for oral administration and B for parenteral administration.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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