阿瑞匹坦胶囊多少钱一盒？在哪买？

Aprepitant is the first NK-1 receptor antagonist, which binds highly selectively to NK-1 receptors in the brain and antagonizes substance P. Substance P is a neurokinin located in the nerves of the central and peripheral nervous systems. It acts through NK-1 receptors and is related to various inflammatory immune responses such as vomiting, depression, pain and asthma. It can effectively prevent vomiting, and the antiemetic regimen combined with 5-HT3 receptor antagonists and glucocorticoids has also been recommended by international authoritative guidelines.

In 2003, two randomized controlled clinical studies compared the preventive effect of standard antiemetic regimen (ondansetron + dexamethasone) ± aprepitant on CINV in patients receiving highly emetic chemotherapy drugs (HEC, cisplatin ≥70 mg/m2). The results showed that the combined aprepitant group had significantly better CR (68% vs. 48%, P<0.001) and no vomiting rate (72% vs. 50%, P<0.01) for acute and delayed CINV caused by HEC than the standard antiemetic group. A high-dose cisplatin (≥70 mg/m2) study conducted by Chinese scholars in 2011 also obtained similar results. The CR (69% vs. 57%, P=0.007) and vomiting-free rate (71% vs. 57%, P=0.003) of aprepitant + standard antiemetic regimen (granisetron + dexamethasone) for CINV were significantly higher than those of the standard antiemetic group (Figure 1). In women with breast cancer treated with AC regimen, aprepitant combined with standard antiemetic regimen was also superior in CR (P=0.015) and vomiting-free rate (P<0.001) in preventing CINV. Based on clinical research results, aprepitant was recommended as one of various antiemetic regimens in the 2011 MASCC updated CINV prevention guidelines.

After understanding the good therapeutic effects of aprepitant, how much does a box of aprepitant capsules cost? Where to buy? It is understood that the original drug aprepitant capsules currently on sale in China are 3 capsules per box (0.125gx1 capsule + 80mgx2 capsules), and each box sells for about $600. The price is still relatively high. Since aprepitant is not covered by medical insurance, patients can only pay for the medicine themselves. In addition, patients can also choose other versions on sale, which are more affordable than the original drug and have the same efficacy as the original drug. Patients who need medicine can contact the medical companion service for consultation.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.