止吐药阿瑞匹坦需要空腹吃吗？

Aprepitant capsule (Aprepitant) is a highly selective substance P neurokinin 1 receptor antagonist that is clinically administered in combination with other antiemetic drugs. The original drug of aprepitant was developed by Merck & Co. of the United States. In March 2003, aprepitant was approved for marketing by the U.S. FDA under the trade name Emend. Currently, aprepitant has been approved for marketing in more than 90 countries and regions around the world. It is reported that Emend’s global sales in 2018 were US$522 million. In September 2013, the capsule was approved in the country, and the domestic trade name is Yimei.

After being launched on the market, aprepitant has been in the first-line recommended position in the anti-emetic regimen of chemotherapy drugs with high risk of vomiting, and its efficacy and safety have been clinically recognized. Aprepitant has been unanimously recommended by authoritative European and American guidelines such as the National Cancer Comprehensive Network Clinical Application Guidelines (NCCN). So does the antiemetic aprepitant need to be taken on an empty stomach?

According to the drug instructions for aprepitant, aprepitant capsules can be taken with food or on an empty stomach. The usage and dosage of aprepitant capsules are as follows: 125 mg orally taken 1 hour before chemotherapy, and 80 mg taken in the morning on days 2 and 3. 40m is for use only 3 hours before anesthesia surgery. Of course, patients should still follow the doctor's instructions when taking aprepitant, and must not blindly take the medicine privately. Only correct use of the medicine will help the condition.

The most common drug-related adverse reactions of antiemetics included: hiccups (4.6%), weakness/tiredness (2.9%), increased liver index ALT (2.8%), constipation (2.2%), headache (2.2%), and anorexia (2.0%). Other adverse reactions include: redness, upper respiratory tract infection, tachycardia, weakness, pelvic pain, bone pain, pelvic pain, rash, hypokalemia, anxiety, etc. Bradycardia, disorientation, perforated duodenal ulcer, and Stevens-Johnson syndrome have also been reported.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.