美沙拉秦(Salofalk)的功效与作用

The trade name of mesalazine (Salofalk) is Salofalk, which is developed and produced by the German company Dr. Falk Pharma GmbH.

The efficacy and role of mesalazine (Salofalk)

The active ingredient is 5-aminosalicylic acid (5-ASA). Its core mechanism is to exert an anti-inflammatory effect locally on the intestinal mucosa.

1. Inhibit inflammatory mediators: Reduce the synthesis and release of pro-inflammatory substances such as prostaglandins and leukotrienes.

2. Scavenging oxygen free radicals: Neutralizing oxygen free radicals produced during inflammation and causing tissue damage.

3. Immune regulation: Indirectly affects the activity of immune cells and reduces abnormal inflammatory immune responses.

Mesalazine (Salofalk) Indications

Mesalazine is mainly suitable for the acute attack treatment and remission maintenance treatment of the following diseases:

1. Mild to moderate ulcerative colitis: including rectosigmoiditis, left hemicolitis and pancolitis.

2. Crohn's disease: Mesalazine is used for Crohn's ileitis and colitis.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Mesalazine (Salofalk) Usage and Dosage

1. Adults and the elderly (unless otherwise prescribed, take 1-3 times a day):

(1) Acute stage of ulcerative colitis: 1.5-3g daily.

(2). Acute stage of Crohn’s disease: 3–4.5g per day.

(3). To maintain the remission period of ulcerative colitis: 1.5g per day.

(4). To maintain remission of Crohn’s disease: 1.5–3g daily.

2. Medication for children (6 years old and above, weight ≥40kg can be given as adult dose):

(1). Acute stage of ulcerative colitis: 30–50mg/kg daily.

(2). To maintain remission: 15–30 mg/kg daily.

3. Correct method of taking the medicine

(1) Swallow the tablet whole: Be sure to swallow the tablet whole with enough water. Do not chew, crush or break it. Otherwise, the enteric coating will be destroyed and the drug will be released prematurely in the stomach. It will not only irritate the gastric mucosa, but also prevent it from reaching the lesion.

(2) Take before meals: In order to reduce the impact of food on gastric emptying speed and ensure that the tablets enter the intestine smoothly and quickly, it is recommended to take it at least 1 hour before meals.

Adverse reactions of mesalazine (Salofalk)

1. Common adverse reactions

(1) Gastrointestinal system: abdominal pain, diarrhea, nausea, vomiting, indigestion, bloating. It should be noted that symptoms may sometimes overlap with those of the disease itself.

(2) Nervous system: headache.

(3) Skin: rash, itching, urticaria.

2. Rare but serious adverse reactions

(1) Blood system effects: thrombocytopenia, aplastic anemia, hemolytic anemia.

(2) Kidney toxicity: acute/chronic interstitial nephritis, renal insufficiency or even renal failure.

(3) Liver damage: hepatitis, elevated liver enzymes, intrahepatic cholestasis.

(4) Heart and lung reactions: pericarditis, myocarditis, pulmonary fibrosis, pneumonia, pleurisy, etc.