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How to take Novartis: Deferasirox should be taken on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day. Tablets should not be chewed or swallowed whole.

Recommended for patients with iron accumulation, such as those who require long-term blood transfusion (blood transfusion volume up to 100 ml/kg) and serum ferritin exceeds 1000 μg/L; corresponding to body weight, it is initially recommended to take a daily dose of 20 mg/kg of deferasirox. Depending on the improvement of serum ferritin indicators, patients may need to adjust or increase the dose of deferasirox. Generally, the dose will be increased in units of 5 mg/kg or 10 mg/kg, but the total dose should not exceed 30 mg/kg per day.

The absolute bioavailability (AUC) of Novartis deferasirox in Switzerland is 73.5±12.8%. After multiple doses, deferasirox exposure increased, with an accumulation factor of 1.3-2.3. The absolute bioavailability (AUC) of deferasirox orally dispersible tablets is approximately 70% of intravenous administration. The bioavailability (AUC) of deferasirox is moderately increased (approximately 13-25%) when taken 30 minutes before a meal with a normal or high-fat meal.

Patients using Novartis should avoid combination with strong inducers of UDP-glucuronosyltransferase (UGT) (such as rifampicin, phenytoin, sedatives and hypnotics, protease inhibitors) and cholestyramine. Do not administer concurrently with aluminum-containing antacids. Not to be combined with other iron chelation treatments. Be careful with repaglinide, drugs with potential ulcerogenic effects such as NSAIDs, cortisones, or oral bisphosphonates, drugs metabolized by CYP3A4 (such as cyclosporine, simvastatin, hormonal contraceptives). Withhold Enrig at least 5 days before performing Gallium-67 imaging.

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