Overview of contraindications, precautions and therapeutic effects of tranexamic acid tablets

Introduction: Tranexamic acid tablets are a commonly used hemostatic drug. Its main function is to help stop bleeding by inhibiting the activation of plasminogen and reducing the degradation of fibrin. This article mainly talks about the contraindications, precautions, effects, drug overdose and drug interactions of tranexamic acid tablets.

Contraindications

Contraindicated in patients allergic to tranexamic acid tablets or any of its excipients. Patients with thrombotic tendencies such as acute myocardial infarction should use it with caution. Secondary fibrinolytic bleeding caused by disseminated intravascular coagulation (DIC) should be used with caution before heparinization. Use with caution in patients with massive hematuria in hemophilia or parenchymal lesions of the renal pelvis, as tranexamic acid may cause secondary clot obstruction of the renal pelvis and ureter.

Notes

1. Patients taking tranexamic acid tablets need to be monitored for the possibility of thrombotic complications.

2. Tranexamic acid is generally not used alone for secondary fibrinolytic bleeding caused by disseminated intravascular coagulation (DIC) to prevent further thrombosis.

3. If it is used in combination with other coagulation factors such as factor IX, you should be alert to thrombosis. It is generally believed that it is more appropriate to use tranexamic acid 8 hours after the use of coagulation factors.

4. Those who must continue to use tranexamic acid tablets for a long time should undergo eye examination and monitoring.

5. It is incompatible with thrombolytic agents such as penicillin or urokinase; the combination of oral contraceptives, estrogen or prothrombin complex concentrates with tranexamic acid may increase the risk of thrombosis.

6. Patients with liver and kidney dysfunction should use it with caution and adjust the dosage appropriately.

Efficacy

Tranexamic acid can inhibit the activation of plasminogen, thereby reducing the degradation of fibrin, and is used to treat or prevent excessive blood loss caused by various causes (such as severe trauma, postpartum hemorrhage, surgery, tooth extraction, nosebleeds and menorrhagia). Tranexamic acid also has anti-inflammatory effects and can be very effective in treating contact dermatitis, chronic eczema, urticaria, etc. Tranexamic acid can inhibit plasmin, thereby inhibiting blood vessel formation and reducing the number of erythema and blood vessels.

Drug overdose

If you take too much, you may have diarrhea, sexual dysfunction, nausea, vomiting, dizziness, and occasionally intracranial thrombosis and bleeding. If you have the above discomfort, please stop taking the drug immediately and seek medical treatment.

Drug Interactions

It is forbidden to use it in combination with hormonal contraceptives, as combined use will increase the risk of thrombosis. When combined with other coagulation factors (such as factor IX), caution should be taken to avoid thrombosis.

Tranexamic acid tablets are prescription drugs and need to be used under the guidance of a doctor. Patients should strictly follow the doctor's prescriptions and instructions, and pay attention to possible adverse reactions and drug interactions during medication. If you have any questions or concerns, you should consult your doctor or pharmacist promptly.