非布司他用量多少呢？

, is mainly used for the long-term treatment of gout and hyperuricemia. So, how much is the dosage of febuxostat?

For patients with gout, the starting dose of febuxostat is 40 mg orally once daily. Since the drug-enzyme complex formed by febuxostat and xanthine oxidase is extremely stable and its uric acid-lowering effect is stronger than that of allopurinol, blood uric acid can be rechecked after 2 weeks of taking it. If the blood uric acid level is still not less than 360 μmol/L after 2 weeks, it is recommended to increase the dose to 80 mg, once a day.

If febuxostat still cannot achieve the treatment goal after increasing to an appropriate dose, a drug that promotes uric acid excretion may be considered. It should be noted that febuxostat may cause increased plasma concentrations of azathioprine, mercaptopurine and theophylline and increase toxicity. Therefore, concomitant use with azathioprine, mercaptopurine and theophylline is prohibited.

While treating gout, you can take febuxostat tablets, or use them with other analgesics, such as aspirin tablets, piroxicam, etc. In severe cases, you can use hormonal drugs for treatment.

Generally, febuxostat tablets are used for treatment, and the medication needs to be taken continuously for about six months. If gout relapses and obvious pain occurs during the medication period, you can take painkillers and treat it symptomatically, which will not affect the efficacy of febuxostat tablets.

Drugs that inhibit the production of uric acid can directly inhibit the production of uric acid in the body without increasing the burden on the kidneys. They are the first-choice drugs recommended by national guidelines. There are currently two types of this drug: allopurinol and febuxostat. Allopurinol is cheap, has been used for many years, and has good efficacy in some patients. Unfortunately, because many Asians carry the HLA-B5801 gene, the incidence of allergy to allopurinol is higher, and allopurinol can cause serious adverse reactions, and some severe patients can die. Medical disputes caused by this drug are common. Therefore, this drug is relatively dangerous and its application in China has been restricted. Therefore, it is the best choice!