How long does it take for zoledronic acid to work?

Zoledronic Acid is adapted to the pain caused by osteolytic bone metastasis of malignant tumors. The injection was approved by the China State Food and Drug Administration on May 22, 2009, for the treatment of postmenopausal osteoporosis in women.

The difference between Zoledronic Acid and other bisphosphonates is that its R2 side chain group is a dinitrogen-containing imidazole ring. This structure enables the drug to firmly bind to hydroxyapatite on the bone surface. In vitro studies have confirmed that compared with other bisphosphonates, zoledronic acid has a stronger binding force to hydroxyapatite on the bone surface and has a stronger inhibitory effect on osteoclasts. Zoledronic acid accumulates in active sites of bone resorption and is taken up by osteoclasts during the bone resorption process. It directly inhibits farnesyl pyrophosphate (FPP) synthase, limiting the synthesis of osteoclast microstructural proteins, causing the cells to lose function and eventually undergo apoptosis. Some drugs can be reused after being released from osteoclasts, so a single small dose of zoledronic acid can achieve stronger and more lasting effects.

Intravenous infusion of Zoledronic Acid. For adults, 4 mg each time should be diluted with 100 ml of 0.9% sodium chloride injection or 5% glucose injection and then infused intravenously. The infusion time should be no less than 15 minutes. Administer every 3-4 weeks or as directed by your doctor. Zoledronic acid should not be used in conjunction with infusion solutions containing calcium or other divalent cations (such as lactated Ringer's solution). A single intravenous infusion should be performed using an infusion tube separate from other drugs. Hepatic Impairment: Due to limited clinical study data in patients with severe hepatic impairment, no special recommendations are available for these patients.

How long does it take for zoledronic acid to work?

The onset of effect is related to the patient's own condition, and will vary among different patients.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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