Dosage standards for Capmatinib (Touradda), 2 or 4 pills per day?

Capmatinib (Capmatinib) is a selective MET inhibitor, mainly used to treat the presence of MET exon 14 Patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with skipping mutations (METex14). The drug was developed by Novartis and has been approved for marketing in many countries and regions. As a targeted drug, its dosage and course of treatment are usually formulated according to the instructions and clinical guidelines, and must be strictly followed by the doctor's instructions and cannot be adjusted on your own.

The recommended dose currently used globally is 400mg, taken orally twice a day. Since the common specifications on the market are 200mg tablets, this means that patients need to take 2 tablets every day (2 tablets in the morning) + 2 tablets (2 in the evening) capsules) = A total of 4 capsules, completed twice in the morning and evening. In other words, it is not simply "2 pills or 4 pills per day", but is implemented according to the standard of total dose 800mg administered in two divided doses.

During the treatment, if the patient experiences serious adverse reactions (such as abnormal liver function, pneumonia-like symptoms, edema, etc.), the doctor may adjust the dose to 300mg, twice a day (i.e. the total daily dose 600mg) according to the situation, and then gradually resume based on tolerance. In elderly patients or patients with concomitant renal impairment, initial dose adjustment is usually not required, but side effects still need to be monitored closely.

When taking capmatinib, you should try to take it at the same time, either before or after meals. If you miss a dose, you should take it within 6 hours. If it exceeds 6 hours, skip it to avoid overdose. Patients should avoid concurrent use with strong CYP3A4 inhibitors or inducers to avoid affecting drug concentrations. In addition, during treatment, liver, kidney function and heart conditions should be reviewed regularly, follow the physician's guidance, and avoid increasing or decreasing the dose on your own to ensure efficacy and safety.

Reference link:https://www.drugs.com