What is the general market price of generic drugs of Canafenib/Encofenib?

Encorafenib is an oral small molecule inhibitor targeting the BRAF gene mutation. Its main indication is to treat patients with advanced melanoma (Melanoma) with BRAF V600E mutations, especially when combined with the MEK inhibitor binimetinib, it is more effective and can delay disease progression and improve median survival.

In addition,Encofenib is also approved for use in patients with advanced or metastatic colorectal cancer, especially in combination with cetuximab (Cetuximab) for the treatment of colorectal cancer patients with BRAF V600E mutations who have failed one or more systemic treatments. In the field of non-small cell lung cancer (NSCLC), although it is still in the clinical trial stage, studies have pointed out that encofenib may also have potential efficacy in BRAF mutation-positive NSCLC patients, providing the possibility of expanding its indications.

Regarding the market price of generic drugs, the current price of Encofenib’s original drug is generally on the high side. Therefore, patients are more inclined to choose relatively affordable generic drugs in the context of a heavy financial burden. In regions such as Laos, the production of generic drugs of Encofenib has reached a certain scale. The main manufacturers include Luscius and Bear Pharma. At present, the more common specification on the market is 75 mg, with 42 pills per bottle. The price of a box is approximately RMB 4,000, which is several times cheaper than the original drug. The main advantage of generic drugs is that their active ingredients are consistent with the original drugs, but the price is more accessible and suitable for patients who require long-term oral targeted drugs.

It is worth noting that although Lao generic drugs have not been officially approved by China's National Food and Drug Administration (NMPA), because they have been widely used in many countries, some patients obtain them through overseas drug purchase channels and use them under the guidance of doctors. When choosing generic drugs, patients need to pay special attention to the legality and stability of the drug source channels to ensure the safety and efficacy of the drugs.

Reference materials:https://www.braftovi.com/