Pegloticase’s market price trend and guidance on formal purchasing channels

The American version of Pegloticase (Pegloticase) has a specification of 8 mg/mL. Its latest selling price is really astonishing, about 20 as high as million. At present, this drug has not been approved for marketing in China, which makes it difficult for many patients in need to purchase the drug. However, patients are not without options and can obtain the drug through formal overseas channels.

Pegloticase (Pegloticase) is a biological agent used to treat chronic gout and belongs to the recombinant urate oxidase class of drugs. Under normal physiological conditions of the human body, urate oxidase can decompose uric acid into more soluble allantoin and excrete it from the body. However, humans lack this enzyme due to genetic mutations, causing uric acid to easily accumulate and cause gout. Preikexi makes up for this lack.

In terms of efficacy, it performs well. For patients with chronic gout who are ineffective or intolerant to traditional uric acid-lowering drugs, Prekexi can quickly and significantly reduce blood uric acid levels. Clinical trials have shown that most patients' blood uric acid can quickly drop below the target value after taking the drug, and some are close to the normal range. As blood uric acid decreases, urate crystals in the joints gradually dissolve, which can effectively relieve acute symptoms such as joint pain and swelling, reduce the frequency of gout attacks, and greatly improve the patient's quality of life. Long-term use can also improve joint function, and can also dissolve existing tophi, helping to restore joint mobility.

However, Preikeshi was not perfect. It may cause some adverse reactions, the most common of which are infusion reactions, manifested as fever, chills, rash, etc. It may also affect the immune system and increase the risk of infection. Moreover, it is relatively expensive. The US version of 8 mg/mL specifications is priced at about 200,000. It has not yet been launched in China. Patients need to purchase it through regular overseas channels, and the process is relatively complicated.

Overall, Preikesi provides a new and effective treatment option for patients with chronic gout. Patients should fully communicate with their doctors before use, comprehensively consider their own condition, financial status, medication tolerance and other factors, and carefully decide whether to use this drug for treatment, so as to maximize the safety of medication and reduce adverse reactions while controlling the condition.

Reference materials:https://en.wikipedia.org/wiki/Pegloticase