What is the specific dosage of 3922 and lorlatinib/lorlatinib?

"3922" is the internal research and development code name of Lorlatinib/lorlatinib (Lorlatinib), which is derived from Pfizer's number of the drug during the development phase, which is called PF-06463922. This number is often used in drug records in the early clinical trial phase. As the drug officially acquired the trade name "Lorlatinib" and was launched on the market, the code name 3922 was gradually replaced, but it is still occasionally mentioned in research and overseas drug literature, especially in scientific research articles or drug development history.

The standard recommended dosage of lorlatinib is 100 mg orally once daily, each time It can be taken on an empty stomach or after a meal. This dose is the conventional therapeutic dose for the treatment of adult patients with ALK-positive non-small cell lung cancer. It is designed to ensure that the drug maintains a stable concentration in the plasma, thereby continuously inhibiting the abnormal cell signaling caused by ALK mutations and ROS1 fusion mutations. This dose has been proven to have good tolerability and therapeutic effect through multiple international multi-center clinical trials, and has therefore become the standard dose recommended in treatment guidelines in various countries.

In certain circumstances, the physician may adjust the dose based on the patient's individual tolerance, adverse reaction profile, and combination medication plan. For example, in the event of severe central nervous system side effects (such as cognitive impairment, mood changes, or epileptic seizures), the dose may be temporarily reduced to 75 mg or 50 mg to alleviate the toxic side effects and maintain a certain therapeutic effect. In addition, patients with hepatic and renal insufficiency need to adjust the dose under the guidance of a doctor and monitor drug metabolism.

Special attention should be paid to the fact that lorlatinib is metabolized byCYP3A enzyme and may interact with other drugs metabolized by the same enzyme system (such as certain antifungal drugs, antiepileptic drugs, antibiotics, etc.), thus affecting its blood concentration and thus affecting its efficacy and safety. Therefore, when taking medications together, be sure to consult your doctor to confirm the rationality of the combination.

References：https://www.lorbrena.com/