What dietary taboos should you pay attention to while taking capmatinib?

Capmatinib is a tyrosine kinase inhibitor that targets MET gene mutations and is mainly used to treat patients with advanced non-small cell lung cancer carrying MET exon 14 skipping. During the medication period, in order to ensure stable drug efficacy and reduce adverse reactions, patients need to pay special attention to dietary taboos and management.

Grapefruit and its products should be avoided. Grapefruit contains certain components that inhibit the activity of the CYP3A enzyme, and capmatinib is one of the drugs metabolized by this enzyme. If eaten together with grapefruit, it may lead to an increase in blood drug concentration, increase the risk of drug toxicity, and induce serious side effects, such as liver function damage or gastrointestinal discomfort. Therefore, grapefruit, grapefruit juice, and drinks or supplements containing their ingredients should be completely avoided while taking this medication.

High-fat meals may have an impact on drug absorption. Although capmatinib can be taken on an empty stomach or after meals, it is recommended to avoid taking it with high-fat foods to avoid increasing gastrointestinal burden or affecting stable drug absorption. Patients should choose light, easy-to-digest foods before and after taking the medicine, and avoid fried, heavy-flavored, and high-cholesterol foods. This is especially true for patients with digestive system diseases or abnormal liver function.

Alcohol intake should be limited. Alcohol will increase the metabolic burden on the liver, and capmatinib itself may cause elevated liver enzymes or even damage liver function. Drinking alcohol may enhance the adverse effects of medications on the liver and increase the incidence of side effects, especially in patients who have been taking medications for a long time or whose liver function is already weak. Therefore, it is recommended to avoid drinking alcohol as much as possible while taking the medicine. If necessary, you can consult your doctor whether it is allowed to drink small amounts occasionally.

Finally, maintaining a nutritionally balanced and regular diet can help improve drug resistance and efficacy. You should eat more foods rich in protein, fresh vegetables and fruits, drink moderate amounts of water, and maintain good intestinal function. Some patients may experience loss of appetite, nausea, etc. during the medication process. It is recommended to eat small amounts more frequently and reasonably adjust the diet structure to improve the overall physical condition and better cooperate with treatment.

Reference materials:https://www.novartis.com/our-products/pipeline/capmatinib