Teriflunomide’s mechanism of action

Teriflunomide (Teriflunomide) blocks the process of DNA synthesis by inhibiting intracellular dihydroxyacetyl dehydrogenase (DHODH), this will lead to a decrease in the activity of immune cells such asT lymphocytes and B lymphocytes. Teriflunomide can reduce the activity of the immune system and reduce the number and activity of immune cells. Its inhibitory effect on T lymphocytes is mainly achieved by reducing their proliferation and migration in lymph nodes. This helps reduce autoimmune reactions and inflammation.

Teriflunomide has a certain anti-inflammatory effect and can reduce the production of inflammatory mediators and the infiltration of inflammatory cells. It may achieve anti-inflammatory effects by regulating inflammation-related signaling pathways and reducing the release of inflammatory factors. These mechanisms of action of teriflunomide help reduce the progression and inflammatory response of multiple sclerosis (MS), thereby reducing nerve damage and MS-related symptoms. Please note that teriflunomide should only be used according to a doctor's prescription and guidance, and treatment effects vary based on individual differences.

The original drug Teriflunomide has been marketed in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to multiple sclerosis patients who are ineffective in conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. Specifications The price of 14mg*28 tablets per box is around 10,000 yuan, which is expensive. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of each box of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 (the price may fluctuate due to exchange rates).