How long does it take to stop taking Tolvaptan tablets?

Patients receiving Tolvaptan should be monitored to assess serum sodium concentrations and neurologic status, particularly during initiation of treatment and after dose titration. Subjects with SIADH or very low baseline serum sodium concentrations may be at greater risk for rapid correction of serum sodium. In patients receiving tolvaptan, if a rapid rise in serum sodium occurs, tolvaptan therapy should be stopped or interrupted, and hypotonic fluids should be considered.

The initial dose of tolvaptan tablets is 60 mg orally daily, with 45 mg taken upon awakening and 15 mg 8 hours later. Titrate to 60 mg plus 30 mg daily, or to 90 mg plus 30 mg if tolerated. Fluid restriction within the first 24 hours of tolvaptan treatment may increase the possibility of rapid correction of serum sodium and should generally be avoided. Concomitant use of diuretics also increases the risk of rapid correction of serum sodium, and serum sodium should be monitored closely in such patients. Before deciding to discontinue medication, patients should maintain close communication with their physician and follow the guidance and recommendations provided by their physician.

Tolvaptan tablets have been marketed in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The price of Indian pharmaceutical factory production specifications15mg*4 tablets per box is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.