How much does Tolvaptan cost?

Tolvaptan is a selective vasopressin V2 receptor antagonist that delays the increase in kidney volume (a surrogate marker of disease progression), slows the decline in kidney function, and reduces pain in patients with autosomal dominant polycystic kidney disease (ADPKD) with relatively preserved kidney function. Tolvaptan was originally developed to induce free water excretion in patients with dilutional hyponatremia and in patients with heart failure.

Tolvaptan tablets affect kidney function by blocking vasopressinV2 receptors. People with polycystic kidney disease develop many fluid-filled cysts in their kidneys. These cysts gradually grow in size and expand, putting pressure on the surrounding kidney tissue and ultimately leading to impaired kidney function. Tolvaptan tablets reduce water reabsorption, which increases urine output and reduces the stress the cyst puts on the kidneys. Tolvaptan tablets block the vasopressin V2 receptor, reduce the reabsorption of water by the renal tubules, increase the excretion of water in the urine, and help reduce the excessive fluid load in the body.

Tolvaptan tablets have been launched in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The production specifications of Indian pharmaceutical factoriesThe price per box of 15mg*4 tablets is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.