What is the daily dose of Tolvaptan?

Tolvaptan is an orally active, non-peptide, arginine-selective arginine vasopressin V2R antagonist that acts by binding to the V2R expressed distally in the nephron with a higher affinity than vasopressin.

(1) Hyponatremia: The usual starting dose of tolvaptan tablets is 15 mg once daily, regardless of meals. After at least 24 hours, increase dose to 30 mg once daily to a maximum of 60 mg once daily to achieve desired serum sodium levels. Do not take tolvaptan tablets for more than 30 days to minimize the risk of liver damage.

(2), autosomal dominant polycystic kidney disease: The initial dose of tolvaptan tablets is 60 mg orally daily, 45 mg when you wake up, and 15 mg 8 hours later. Titrate to 60 mg plus 30 mg daily, and if tolerated, titrate to 90 mg plus 30 mg, with an interval of at least once a week between titrations. Patients may be titrated down based on tolerance and encouraged to drink enough fluids to avoid thirst or dehydration.

Tolvaptan tablets have been marketed in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The price of Indian pharmaceutical factory production specifications15mg*4 tablets per box is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.