Tolvaptan tablets (Tolvaptan) treatment plan for polycystic kidney disease

Tolvaptan tablets (Tolvaptan slows the decline of kidney function in adults at risk for rapidly progressive autosomal dominant polycystic kidney disease (ADPKD) It can be used to slow the growth of cysts, reduce the growth of the entire kidney, and protect kidney function longer. However, this drug cannot completely cure autosomal dominant polycystic kidney disease (ADPKD), nor can it prevent cysts from forming in the kidneys.

To reduce the risk of serious or irreversible liver injury, perform ALT, AST, and bilirubin blood tests before starting tolvaptan, at 2 and 4 weeks after starting, monthly for 18 months, and every 3 months thereafter. Monitor for complications that may indicate liver injury. The initial dose of tolvaptan tablets is 60 mg orally daily, 45 mg upon awakening and 15 mg 8 hours later. Titrate to 60 mg plus 30 mg daily, and if tolerated, titrate to 90 mg plus 30 mg, with an interval of at least once a week between titrations. Patients may be titrated down based on tolerance and encouraged to drink enough fluids to avoid thirst or dehydration.

Tolvaptan tablets have been marketed in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The price of Indian pharmaceutical factory production specifications15mg*4 tablets per box is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.