What diseases does Tolvaptan mainly treat?

Tolvaptan Tablets (Tolvaptan) is indicated for the treatment of clinically significant hypervolemic and isovolemic hyponatremia with a serum sodium value less than 125 mEq/L or less obvious hyponatremia that is symptomatic and cannot be corrected by fluid restriction, including patients with heart failure and syndrome of inappropriate antidiuretic hormone (SIADH).托伐普坦片可减缓处于快速进展的常染色体显性多囊肾病（ADPKD）风险中的成人的肾功能衰退。

对于需要紧急干预升高血清钠以预防或治疗严重神经症状的患者不应使用托伐普坦片治疗。 Two studies involving 424 adults showed that tolvaptan tablets were effective in raising sodium levels in people with low sodium levels caused by SIADH and other conditions, such as liver and heart problems.然而，托伐普坦片在SIADH患者中比在有肝脏或心脏问题的患者中更有效。正常的钠水平在135到145毫摩尔/升之间。

Tolvaptan tablets have been marketed in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The price of Indian pharmaceutical factory production specifications15mg*4 tablets per box is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.