Which company makes Baricitinib?

Baricitinib (Baricitinib) is an oral Janus< developed by the American Incyte pharmaceutical company. span>related kinase(JAK)inhibitor, used to treat autoimmune diseases such as rheumatoid arthritis(RA), atopic dermatitis, systemic lupus erythematosus and other autoimmune diseases.

The mechanism of action of baricitinib is to interfere with the cytokine signaling pathway, especially tumor necrosis factor (), by inhibiting the activity of Januskinase (JAK). pan>TNF) and interleukin-6 (IL-6) signaling, thereby reducing the inflammatory response of arthritis.

The pharmacological properties of the drug indicate that baricitinib is rapidly absorbed after oral administration and reaches peak concentrations within1-2 hours. It is metabolized by the liver to form active metabolites and excreted primarily through the kidneys. The half-life of the drug in the body is approximately 12-18 hours.

The recommended dose of baricitinib is 2mg orally daily (mg). In patients with impaired renal function, dosage needs to be adjusted accordingly.

Some side effects may occur when using baricitinib, including infection, headache, high blood pressure, respiratory symptoms, nausea, vomiting, etc. Serious side effects may include serious infections, lymphoma, pulmonary embolism, and more. Patients should pay close attention to their own conditions during use and seek medical attention immediately if they feel uncomfortable.

Baricitinib has been launched in China and is included in medical insurance. Patients can purchase it domestically. Due to different medical insurance reimbursement policies in different regions, the reimbursement ratio is also different. The price is about 1200~1600 yuan. For specific prices, please consult the local pharmacy or the medical insurance bureau. Baricitinib has both original and generic drugs abroad. The original drug is mainly Eli Lilly’s original drug, and its price is higher than in China. Generic drugs are mainly Bangladeshi generic drugs, the price is 450Yuan or so. The ingredients of original drugs and generic drugs are basically the same.