Is Baricitinib effective in treating alopecia areata?

The U.S. Food and Drug Administration(FDA)has approved once-daily tablet baricitinib (Baricitinib) as a first-in-class systemic treatment for severe alopecia areata in adults(AA). Recommended dose is 2mg/ day, may be increased to 4 if treated mg/day For patients with near-total or complete scalp hair loss, with or without extensive eyelash or eyebrow hair loss, consider taking 4mg daily. Once adequate efficacy of 4-mg/day is achieved, the dose will be reduced to 2-mg/day. It is not recommended to use this product in combination with other JAK inhibitors, biological immunomodulators, cyclosporine or other potent immunosuppressants.

The approval is based on Eli Lilly's BRAVE-AA1 and BRAVE-AA2 trials, the largest completed to datePhase 3AA clinical trial plan, 5-7evaluated1,200people with severeAA(Alopecia Severity Tool(SALT)< Efficacy and safety of baricitinib in adult patients with /span>score≥50, defined as scalp alopecia≥50%). In the 36-week study, 17-22% of patients took baricitinib daily 2-mg, 32-35% of patients taking baricitinib 4-mg daily, reaching 80 In contrast, 3-5%of patients taking placebo achieved 90% or greater hair coverage. also,11-13%的患者每天服用2-mg巴瑞替尼，24-26%的患者每天服用4-mg巴瑞替尼，相比之下，服用安慰剂的患者中只有1-4%达到了90%或更高的头发覆盖率； 在BRAVE-AA2的多重控制方案下，巴瑞替尼 2-mg/天的结果不具有统计学意义。

Baricitinib has been launched in China and is included in medical insurance. Patients can purchase it domestically. Due to different medical insurance reimbursement policies in different regions, the reimbursement ratio is also different. The price is about 1200~1600 yuan. For specific prices, please consult the local pharmacy or the medical insurance bureau. Baricitinib has both original and generic drugs abroad. The original drug is mainly Eli Lilly’s original drug, and its price is higher than in China. Generic drugs are mainly Bangladeshi generic drugs, and the price is around 450 yuan. The ingredients of original drugs and generic drugs are basically the same.