Efficacy and effects of baricitinib

Baricitinib (Baricitinib) is a Janus kinase inhibitor used to treat rheumatoid arthritis (rheumatoid arthritis) and psoriatic arthritis (psoriatic arthritis). It has the following effects and functions:

1.Anti-inflammatory effect: Baricitinib inhibits the activity ofJanuskinase and interferes with cell signaling pathways, thereby reducing the inflammatory response. Inflammation is a protective response of the immune system against infection and injury, but in some diseases, the immune system is overactivated, leading to an excessive inflammatory response. Baricitinib modulates the production of inflammatory mediators, such as tumor necrosis factor (TNF) and interleukin (-6) (IL-6), thereby reducing inflammation levels.

2.Immune regulatory effect: Baricitinib has a regulatory effect on the immune system and can inhibit the activation of immune cells and the release of inflammatory mediators. The immune system plays a key role in protecting the body from infection and disease, but in autoimmune diseases, the immune system mistakenly attacks its own tissues, causing inflammation and tissue damage. Baricitinib can reduce disease symptoms by regulating the activity of immune cells and reducing the immune system's attack on self-tissue.

3.Reducing arthritis symptoms: Baricitinib has shown significant results in the treatment of rheumatoid arthritis and psoriatic arthritis. These diseases can cause joint inflammation and pain, affecting the patient's quality of life. By reducing joint inflammation, baricitinib can relieve symptoms such as joint swelling, pain and stiffness, and improve joint mobility and function.

4.Reducing disease progression: Baricitinib can slow down further damage to joints and delay disease progression. Rheumatoid arthritis and psoriatic arthritis are both chronic inflammatory diseases that, if not treated and controlled in time, may lead to joint destruction and dysfunction. The use of baricitinib can reduce joint destruction and osteoporosis and protect joint structure and function.

5.Improvement of psoriatic skin lesions: In addition to the treatment of arthritis, baricitinib can also improve psoriatic skin lesions. Psoriasis is a chronic inflammatory skin disease. Baricitinib can improve skin lesions and reduce the formation of scales and erythema by regulating immune responses and reducing inflammatory responses.

It should be noted that the use of baricitinib should be evaluated and decided by the physician based on the patient's specific situation and needs. The drug is usually taken as an oral medication, and the dose is adjusted based on the severity of the disease and the patient's response. While taking baricitinib, patients should pay close attention to any unusual symptoms and have regular medical examinations and monitoring. Only a doctor can evaluate a patient's condition and determine the best regimen for baricitinib.

Baricitinib has been launched in China and is included in medical insurance. Patients can purchase it domestically. Due to different medical insurance reimbursement policies in different regions, the reimbursement ratio is also different. The price is about 1200~1600 yuan. For specific prices, please consult the local pharmacy or the medical insurance bureau. Baricitinib has both original and generic drugs abroad. The original drug is mainly Eli Lilly’s original drug, and its price is higher than in China. Generic drugs are mainly Bangladeshi generic drugs, and the price is around 450 yuan. The ingredients of original drugs and generic drugs are basically the same.

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