Is the price of Trametinib combined with dabrafenib high?

Trametinib plus dabrafenib has an acceptable safety profile, although at lower doses than approved monotherapy, with the maximum tolerated dose being trametinib daily 1.5 mg, Dabrafenib 200 mg twice daily, for the treatment of BRAF Patients with unresectable or metastatic melanoma, metastatic non-small cell lung cancer, locally advanced or metastatic anaplastic thyroid cancer, unresectable or metastatic solid tumors, and low-grade glioma with V600E or V600K mutations.

The specifications listed in the country75mg*120 tabletsDabrafenibThe price of the original drug is around 11,000 yuan, the price of the Turkish version of the original drug of dabrafenib listed overseas is around 10,000 yuan (the price may fluctuate due to the exchange rate), and the price of the generic drug produced by Laos pharmaceutical factory is around 4,700 yuan (the price may fluctuate due to the exchange rate).

The original drug of trametinib has been launched in China and has entered the scope of Class B medical insurance, but it may only be purchased by patients who meet the indications of trametinib, such as BRAF V600 mutation-positive unresectable or metastatic melanoma. Its price is around 10,000 to 20,000 yuan. The reimbursement ratio is different in different regions, and the price is also different, making it expensive. The price of the Turkish version of the original drug Trametinib listed overseas is around RMB 7,900 (the price may fluctuate due to the exchange rate). Generic trametinib is also produced in other countries. The price of the Lao pharmaceutical factory is around RMB 2,950 (the price may fluctuate due to the exchange rate). The ingredients and efficacy of foreign generic drugs are basically the same as those of domestic and foreign original drugs.