Anagrelide instructions and price

Drug name: Anagrelide (Anagrelide)

1. Indications: Anagrelide is mainly used to treat adult patients with idiopathic Thrombocytopenic Purpura (Idiopathic Thrombocytopenic Purpura, ITP). ITP is an immune-mediated thrombocytopenic bleeding disorder characterized by an elevated peripheral blood platelet count, leading to bleeding tendencies.

2. Mechanism of action: anagrelide exerts its therapeutic effect in the following ways:

1.Inhibit phosphodiesterase (phosphodiesterase): Anagrelide inhibits the activity of phosphonucleotide cyclase, an enzyme that catalyzes the cyclization of phosphonucleotides, thereby promoting platelet production and release. By inhibiting the activity of this enzyme, anagrelide reduces the degradation of adenosine diphosphate (cAMP) and increases the concentration of cAMP, thereby inhibiting the process of platelet production.

2.Inhibition of megakaryocyte maturation and differentiation: anagrelide acts on megakaryocytes in the bone marrow, preventing their maturation and differentiation. Megakaryocytes are platelet-producing cells that mature in the bone marrow and release platelets. Anagrelide inhibits platelet production by affecting the growth and differentiation of megakaryocytes.

3.Reducing platelet aggregation: Anagrelide also reduces platelet activity and aggregation by reducing platelet aggregation and adhesion. This helps reduce platelet aggregation in the blood, further lowering platelet counts and inhibiting the formation of blood clots.

3. Pharmacology: Anagrelide mainly works through the following pathways:

1.Inhibition of phosphoribose isomerase (PRIs): As a selective PRIs inhibitor, anagrelide can inhibit the formation of platelets.

2.Block platelet production factors (PDGF) signaling pathway: Anagrelide can inhibit the PDGF signaling pathway and further inhibit platelet production.

4. Dosage and usage: The dosage of anagrelide should be adjusted according to the patient's specific condition and the doctor's recommendations. The usual recommended starting dose is 0.5mg 2 times daily. The dose may be gradually increased based on the patient's platelet count and tolerance. The maximum dose is 2.5mg, 2 times daily. Medication should be done under the supervision of a doctor, and platelet counts should be performed regularly.

5. Side effects: Anagrelide may cause some side effects, including but not limited to:

1.Cardiovascular system side effects: such as tachycardia, arrhythmia, etc.

2.Digestive system side effects: such as nausea, vomiting, abdominal pain, etc.

3.Nervous system side effects: such as headache, dizziness, fatigue, etc.

4.Hematological side effects: such as anemia, leukopenia, etc.

6. Warnings and Precautions: When using anagrelide, you need to pay attention to the following matters:

1.Patients with cardiovascular disease should use it with caution and closely monitor for cardiovascular side effects.

2.Patients taking anagrelide should have platelet counts and other related tests performed regularly.

3.Pregnant and lactating women should use this drug under the guidance of a doctor.

4.Consult your doctor or pharmacist when interacting with other drugs.

7. Contraindications: Anagrelide is contraindicated in the following circumstances:

1.Patients who are allergic to anagrelide or any ingredient in the drug.

2.Pregnant and breastfeeding women, unless your doctor believes the potential benefits outweigh the potential risks.

8. Drug interactions: Pay attention to the following interactions when using anagrelide:

1.Anticoagulant drugs: Anagrelide can increase the antiplatelet effect of anticoagulant drugs and should be used with caution.

2.Sedative-hypnotics: anagrelide may enhance the effect of sedative-hypnotics, so combined use should be avoided.

9. Medication for special groups:

1.Elderly patients: Elderly patients should pay attention to cardiovascular side effects and drug interactions when using anagrelide.

2.Pediatric patients: The safety and effectiveness of anagrelide in children have not been established and its use should be avoided.

10. Availability and price situation: Anagrelide has not yet been launched in China, so patients cannot purchase it domestically and need to purchase the drug through overseas channels. Anagrelide only has the original drug. Outside mainland China, there are the Hong Kong version of the original drug and the foreign Turkish original drug. The price is around 1280 yuan.

The above is the instructions for Anagrelide (Anagrelide), which details the indications, mechanism of action, pharmacology, dosage and usage, side effects, warnings and precautions, contraindications, drug interactions, and medication for special populations. Please consult your doctor or pharmacist for individualized medical advice and guidance before using this medication.