Which diseases require the use of Methylcobalamin Injection (Rozebalamin) and classification of typical indications

Methylcobalamin injection (Rozebalamin) is the latest neuroprotective drug developed in Japan for the treatment of amyotrophic lateral sclerosis (ALS, commonly known as ALS). Its main function is to promote nerve myelin repair and nerve cell metabolism by providing active vitamin B12 form, thereby slowing down the degenerative damage of motor neurons. For ALS patients, methylcobalamin injection can improve the rate of neurological degeneration, delay the progression of the disease, and improve the quality of life to a certain extent.

Clinically, methylcobalamin injection is suitable for patients with early to mid-stage ALSALS. Early use can help stabilize neurological function and delay the occurrence of muscle weakness and movement disorders; mid-term use can help reduce the rate of symptom worsening, such as delaying the decline of respiratory and swallowing muscle functions. For patients with advanced ALS, although drugs cannot reverse lost motor function, they can still be used to protect nerves and maintain residual function.

In addition toALS, the potential application of methylcobalamin injection in other neurodegenerative diseases is also being studied. Some studies have shown that the drug may also provide certain neuroprotective effects in patients with diabetic peripheral neuropathy, neuropathy related to vitaminB12 deficiency, and other motor neuropathies. However, the main approved clinical indications in Japan are still focused on ALS treatment.

When using methylcobalamin injection, patients need to make individualized dosage adjustments under the guidance of a professional doctor, and evaluate the efficacy in conjunction with follow-up of the condition. The injection form can ensure the bioavailability and rapid action of the drug. Clinical practice recommends regular weekly injections, combined with rehabilitation training, respiratory support and symptomatic treatment, to provide a comprehensive management plan for ALS patients. Overall, methylcobalamin injection provides a new neuroprotective option in the treatment of ALS and is of great value in delaying the course of the disease and improving the quality of life.

Keyword tag:

Methylcobalamin injection (indications), ALS (ALS), neurodegenerative diseases, indications, neuroprotection, vitaminsB12

Reference materials:https://www.drugs.com/mtm/mecobalamin.html