What kind of medicine is Tilorisen? Comprehensive introduction to indications, dosage and clinical uses

Pitolisant (Pitolisant) is an orally active drug that is a histamine H3 receptor antagonist/inverse agonist. Its main mechanism of action is to increase the release of histamine in the central nervous system by inhibiting H3 receptor negative feedback, thereby increasing the level of arousal and improving drowsiness symptoms. This drug is based on targeted neuromodulation and can not only improve excessive daytime sleepiness, but also may have an auxiliary effect on attention and cognitive function, so it is of great significance in the field of treatment of neurological sleep disorders.

In terms of clinical indications, tilorisen is mainly used to treat excessive daytime sleepiness caused by narcolepsy (narcolepsy), and can also help improve the symptoms of patients with cataplexy (cataplexy). In clinical trials, it has been shown to have significant efficacy in improving patients' daytime wakefulness, quality of life, and social function. Beyond this, some clinical studies are exploring its potential benefits for other sleep disorders or cognitive disorders, but it is currently mainly approved for the management of narcolepsy-related symptoms.

In terms of dosage, the recommended starting dose for adults is usually 10 mg orally once daily, which can be gradually adjusted to a maximum daily 35.6 mg based on patient tolerance and clinical response. Dosage adjustment should take into account the patient's liver function, as impaired liver function may affect drug metabolism. At the same time, patients should take the medicine at a fixed time to maintain a stable blood concentration and maximize the effectiveness of the medicine. Children and adolescents must strictly follow the guidance of professional physicians when using it. The current approval scope is mainly for adult patients.

In terms of clinical use, tilorisen provides a new treatment option in addition to traditional stimulants. Compared with central stimulants, it acts by regulating the histamine system, has a relatively mild side effect spectrum, and is less likely to cause dependence or excessive cardiovascular burden. Patients should pay attention to mild to moderate adverse reactions such as headache, insomnia, nausea or anxiety during use, and regularly review liver function and blood pressure. Overall, tilorisen has high clinical value in improving daytime wakefulness and quality of life in patients with narcolepsy.

Keyword tags: tilorisen, indications, narcolepsy, dosage, H3 receptor antagonist, central arousal, cataplexy, safety.

Reference materials:https://pubmed.ncbi.nlm.nih.gov/?term=pitolisant