How many tablets of macitentan (Aopus) are in a box? Recommended dosage and treatment duration calculation guide

Macitentan (macitentan) is an oral endothelin receptor antagonist mainly used to treat pulmonary arterial hypertension (PAH). In the domestic market, the common tablet specification of macitentan is 10mg, and each box usually contains 30 tablets. Such packaging makes it easy for patients to take it according to the daily dosage, and it also makes it easy for doctors to adjust the medication plan according to the course of treatment. The design of each tablet of 10mg also helps patients strictly follow the recommended dosage and reduce dosage errors.

In terms of recommended dosage, adult patients generally take 10mg tablets once daily. It is not recommended to exceed this dosage. For some special patients, such as those with mildly impaired liver function, the dose can be adjusted appropriately according to the doctor's evaluation, but usually not less than 5 mg per day to ensure the efficacy of the drug. Macitentan does not need to be taken with food after oral administration. It can be taken at a fixed time to maintain stable blood concentration and achieve the best therapeutic effect.

In terms of course of treatment, macitentan is usually a long-term maintenance treatment drug, with the purpose of continuously inhibiting endothelin receptor activity, improving pulmonary vasoconstriction and remodeling, thereby reducing pulmonary artery pressure and cardiac load. Clinically, the length of treatment is usually determined based on the patient's symptom relief, 6 minute walking distance, cardiac function indicators, and imaging evaluation results. Most patients need to take it continuously for several months or even years, and doctors will regularly review blood routine, liver function and cardiac function indicators to evaluate efficacy and safety.

In practical applications, the treatment course management of macitentan also needs to be combined with the combination of medications. For example, some patients with PAH may also take phosphodiesterase 5 inhibitors or prostaglandin analogs, and doctors will adjust the dosage and treatment intervals according to the combined treatment plan. Patients should strictly follow the doctor's instructions during use and avoid unauthorized increases or decreases in dosage or interruption of treatment to ensure that the drug exerts sustained efficacy while reducing the risk of potential side effects.

Keyword tags: macitentan, specifications, treatment duration, pulmonary hypertension, endothelin receptor antagonists, dose recommendations, long-term treatment, combined medication.

Reference materials:https://go.drugbank.com/drugs/DB08932