Analysis of the reasons and mechanism of sleep improvement after taking methylcobalamin injection (Rozebalamin)

Methylcobalamin injection (Rozebalamin) is a new drug developed by Japan Eisai for the treatment of amyotrophic lateral sclerosis (ALS). Its mechanism of action is not limited to traditional vitamin B12 supplementation. ALSIt is a progressive neurodegenerative disease that mainly affects motor neurons, leading to muscle atrophy, weakness and movement dysfunction. RozebalaminBy providing active methylcobalamin, it participates in nerve cell methylation reactions and myelin maintenance, helping to slow down the degeneration of motor neurons, thereby delaying the progression of the disease.

Its sleep-improving effect is closely related toALS neurological impairment in patients. ALSPatients with ALS are often accompanied by abnormal nerve excitability and muscle spasms, and nighttime discomfort can affect sleep quality. RozebalaminBy supporting neuronal metabolism and myelin repair, Rozebalamin can reduce nerve excitability, relieve nighttime muscle spasms and neuralgia, thereby indirectly improving sleep onset and sleep persistence, making patients more stable at night.

In terms of neurotransmitter regulation, Rozebalamin can promote the metabolic balance of dopamine, serotonin and GABA in the central nervous system. Dopamine is involved in the regulation of wakefulness, and serotonin and GABA are involved in inhibiting central nervous system excitation and promoting sleep. By maintaining stable neurotransmitter levels, Rozebalamin can improve sleep disorders caused by excessive nervous excitement, making it easier for patients to fall asleep and improve sleep depth.

In addition, the drug’s protective effect on peripheral nerve function also helps improve sleep. ALSPart of the symptoms of ALS patients are caused by motor and sensory nerve involvement. Rozebalamin reduces nighttime discomfort and neuropathic pain by promoting nerve regeneration and myelin repair, thereby improving sleep continuity and overall sleep quality. In summary, Rozebalamin not only has a neuroprotective effect in ALS treatment, but can also indirectly improve the patient's sleep status through a variety of mechanisms.

Keyword tags: Methylcobalamin injection, Rozebalamin, sleep improvement, ALS, neuroprotection, neurotransmitter regulation, muscle spasm, quality of life.

Reference materials:https://en.wikipedia.org/wiki/Mecobalamin