Precautions for discontinuation of aprocitentan and suggestions for monitoring blood pressure changes

A high degree of caution is required when discontinuing aprocitentan (aprocitentan), and patients should not suddenly discontinue medication on their own. Long-term use of aprecitentan can effectively control blood pressure, especially for patients with refractory hypertension. Once the drug is stopped suddenly, blood pressure may rebound quickly or even rise significantly, thereby increasing the risk of cardiovascular and cerebrovascular events. Therefore, doctors generally recommend stopping the drug by gradually reducing the dosage, or adjusting the dosage of other antihypertensive drugs during the withdrawal process to ensure that the patient's blood pressure is stable.

During drug withdrawal, blood pressure monitoring is a very important measure. It is recommended that patients use a home sphygmomanometer to measure their blood pressure at a fixed time every day and keep records so that doctors can judge whether the treatment plan needs to be adjusted based on the data. If your blood pressure continues to rise or fluctuates significantly, you should seek medical treatment in time. Through timely monitoring and data feedback, possible health risks during drug withdrawal can be effectively reduced.

At the same time, patients should also pay attention to changes in their clinical symptoms after stopping the drug. Dizziness, headache, palpitations or blurred vision may indicate abnormal fluctuations in blood pressure. You should report it to your doctor immediately and take appropriate measures according to your doctor's advice. For patients with underlying cardiovascular disease, these symptoms need to be monitored closely to prevent serious complications.

In addition to medication management, lifestyle modifications also play a key role during drug withdrawal. Healthy lifestyles such as low-salt diet, regular work and rest, moderate exercise, smoking cessation and limiting alcohol consumption can help maintain blood pressure stability and reduce the impact of drug withdrawal. At the same time, regular follow-up visits and blood pressure follow-up are also very necessary, allowing doctors to detect blood pressure abnormalities in time and intervene, thereby ensuring that the withdrawal process is safe and controllable and reducing cardiovascular risks.

Reference materials:https://en.wikipedia.org/wiki/Aprocitentan