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Tenapanor (Tenapanor) is a selective sodium - hydrogen exchange inhibitor. It mainly acts on the intestines and can reduce the absorption of sodium in the intestines, thereby regulating sodium levels and water balance in the body. This drug is mainly used to treat patients with hyperphosphatemia associated with chronic kidney disease, especially dialysis patients. By reducing the absorption of sodium and phosphorus, it helps control blood phosphorus levels, while improving symptoms related to fluid retention, and provides auxiliary treatment for patients with renal insufficiency.

In terms of usage and dosage, tenapanor is usually taken in the form of oral tablets. The specific dosage needs to be individually adjusted based on the patient's renal function status and blood phosphorus control goals. The commonly recommended clinical dose is 30 mg twice a day, which can be taken with meals to enhance drug absorption and tolerance. During use, you should strictly follow the physician's instructions and do not increase or decrease the dosage on your own to ensure stable drug efficacy and reduce the risk of side effects.

Patients should monitor blood pressure, electrolytes, and serum phosphorus levels while taking tenapanor. Some patients may experience side effects such as mild diarrhea, abdominal pain or gastrointestinal discomfort, which usually do not require special treatment. However, if symptoms persist or worsen, they should seek medical treatment in time. The efficacy of the drug is usually evaluated after several weeks of administration, and the dose or frequency of administration is adjusted based on serum phosphorus levels and clinical symptoms.

In addition, tenapanor is not recommended to be used simultaneously with other powerful electrolyte regulating drugs to avoid affecting the efficacy of the drug or increasing the risk of adverse reactions. Pregnant women, lactating women and patients with severe liver and kidney dysfunction should use it with caution under the guidance of a doctor. Overall, tenapanor provides a safe and effective auxiliary treatment for patients with chronic kidney disease by regulating intestinal sodium and phosphorus absorption, while improving quality of life and delaying the occurrence of complications.

Reference materials:https://www.drugs.com/mtm/tenapanor.html