The correct way to take aprocitentan and safety guide for daily dosage

Aprecitentan is an oral drug used to treat refractory hypertension. It belongs to the endothelin receptor antagonist class and reduces blood pressure by blocking the vasoconstrictive effect of endothelin-1. Before starting to use this drug, patients should evaluate liver and kidney function, blood pressure levels, and whether there are other chronic diseases under the guidance of a doctor to ensure the safety of the drug. Since these drugs may be combined with other antihypertensive drugs, the appropriate dosage must be judged by a doctor with relevant experience when prescribing for the first time to avoid excessive blood pressure lowering or adverse reactions.

Generally speaking, the recommended usage of aprecitentan is to take it orally once a day. There is no need to make special adjustments before or after meals. It can be taken at a fixed time according to personal habits. Taking the medicine at the same time every day can maintain a stable blood concentration and improve the antihypertensive effect. Capsules should be swallowed whole and should not be broken, crushed or chewed to avoid changing the rate of drug release. If you miss a dose due to special circumstances on the day, you should take it as soon as you remember. However, if it is close to the next dose time, just skip it and do not take the medicine again.

In terms of daily dosage, the common recommended dosage is one tablet per day. Doctors may decide whether adjustment is needed based on blood pressure changes, tolerance, and whether other antihypertensive drugs are combined. For patients with moderate hepatic impairment, doctors may be more cautious in evaluating dosage; use is generally not recommended for patients with severe hepatic impairment. In addition, if diuretics, calcium channel blockers or other drugs that affect vasodilation are used together, blood pressure needs to be monitored closely to avoid dizziness, fatigue or even excessive hypotension.

During the medication process, patients should pay attention to possible edema, headache, fatigue, shortness of breath, etc. If the symptoms are obvious or continue to worsen, they should seek medical treatment in time to evaluate whether the treatment plan needs to be adjusted. Especially in the early stages of treatment, it is recommended to monitor blood pressure regularly and record daily values u200bu200bso that doctors can judge the efficacy. Generally speaking, the method of taking aprecitentan is simple, but in order to ensure safety and effectiveness, the dosage needs to be adjusted according to the doctor's advice. Do not increase or decrease the dosage on your own or stop the medication suddenly.

Reference materials:https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/217686s000lbl.pdf