Study on whether Mecobalamin can be taken for a long time and its effect changes after long-term use

Methylcobalamin (Rozebalamin) needs to be clear that it is not completely equivalent to the commonly used clinical methylcobalamin oral tablets. RozebalaminUsually refers to an injection preparation with high-dose methylcobalamin as the core ingredient, used for specific neurological diseases (such as amyotrophic lateral sclerosis, ALS). It is a prescription drug developed and used in specific disease areas, and is not a long-term oral medication for daily health care or common neuralgia. Therefore, whether it can be used for a long time must be strictly based on clear indications and standardized evaluation by doctors.

From the perspective of the feasibility of long-term medication, in ALS and other progressive neurodegenerative diseases, the therapeutic goal of Rozebalamin is to delay the progression of dysfunction rather than relieve short-term symptoms. Such patients often require longer-term and continuous treatment, and long-term or medium- to long-term use does exist in clinical research and medication practice. However, this kind of "long-term use" refers to injection treatment carried out according to an established plan under the guidance of a specialist, and does not apply to extending the course of treatment or expanding the scope of use on your own.

Regarding the effect changes after long-term medication, research shows thatRozebalamin may have a certain delaying effect on the decline of neurological function in the early stages of treatment or the relatively early stages of the disease. As the medication is taken for longer periods of time, its effects tend to be to maintain existing functions and slow down deterioration, rather than to continuously improve symptoms. This efficacy plateau is common in the treatment of neurodegenerative diseases. It does not mean that the drug has failed, but is caused by the progression characteristics of the disease itself.

In terms of safety, current data showRozebalaminThe overall tolerability is acceptable, and no clear severe systemic toxicity has been found with long-term use. However, injection site reactions, mild allergies, or laboratory index fluctuations may still occur. Therefore, functional status and safety indicators need to be regularly evaluated during long-term medication. Generally speaking, whether to use Rozebalamin for a long time and for how long should be decided by a specialist based on the disease stage, efficacy response and risk assessment. It is not recommended to use it for a long time without medical indications.

Reference materials:https://www.drugs.com/