The correct way to take Lorlatinib/Lorlatinib (Borina) tablets

Lorlatinib/Lorlatinib ( Lorlatinib) is a prescription oral medicine that must be taken strictly in accordance with the doctor's instructions. Usually, the recommended standard dose for non-small cell lung cancer is 100 mg orally once a day, which can be taken on an empty stomach or with food. The medication time should be as fixed as possible to maintain stable blood concentration. Patients should swallow the tablet whole when taking the medicine, and do not break it or grind it to avoid affecting the absorption and bioavailability of the medicine. If you accidentally miss a dose, you should take it as soon as possible if the next dose is more than 6 hours away. Otherwise, you should skip the missed dose and avoid taking the medicine again.

Lorlatinib is a metabolic targeted drug, which is mainly metabolized by theCYP3A enzyme system in the body. Therefore, it should be avoided to be used together with strong CYP3A inhibitors (such as ketoconazole) or inducers (such as rifampicin) during the medication period to prevent the drug blood concentration from abnormally increasing or decreasing, affecting efficacy and safety. Patients should avoid drinking grapefruit juice while taking this medication because ingredients in it can interfere with drug metabolism. In addition, it is recommended that patients take medication at a fixed time every day, such as after getting up in the morning or after dinner, to form a regular medication habit and help maintain stable drug efficacy.

While taking lorlatinib, patients should receive regular follow-up visits from their doctors to monitor liver function, cholesterol and triglyceride levels, as the drug may cause an increase in blood lipids or mild fluctuations in liver enzymes. If obvious discomfort occurs, such as nervous system reaction, disturbance of consciousness or severe headache, the drug should be stopped immediately and reported to the doctor. For patients with mild hepatic impairment or renal insufficiency, dose adjustment is usually not required, but they should be closely monitored under the guidance of a professional physician.

The course of treatment for lorlatinib is usually longer, and patients need to insist on taking the medication every day and are not allowed to stop taking the medication without permission due to improvement in symptoms. If you plan to have surgery or radiotherapy, you should inform your doctor in advance so that the medication plan can be adjusted according to the situation.

Reference materials：https://www.lorbrena.com/