布地奈德缓释胶囊(Tarpeyo)的副作用如何缓解

Budesonide extended-release capsules (Tarpeyo) received accelerated approval from the US FDA for the first time on December 15, 2021, and full approval on December 20, 2023. It is the first approved treatment method that can significantly reduce the loss of renal function in IgA nephropathy.

How to alleviate the side effects of Budesonide extended-release capsules (Tarpeyo)

1. Common gastrointestinal discomforts

(1) Performance: including nausea, bloating, indigestion, gastroesophageal reflux, etc. These symptoms are usually related to local effects on the intestines.

(2) Mitigation measures: It is recommended to adopt the principle of eating less and often, and dividing three meals a day into five to six small meals, which can reduce the pressure on the gastrointestinal tract from a single meal. Choose foods that are easy to digest and avoid foods that are too greasy, spicy, sweet or fried.

2. Hypertension and edema

(1) Manifestations: elevated blood pressure and edema in parts of the body (such as ankles and legs).

(2) Mitigation measures: Patients should consciously reduce the amount of cooking salt, soy sauce, MSG and other condiments. Make it a habit to measure and record your blood pressure at the same time every day in a quiet state.

If blood pressure is still poorly controlled after lifestyle intervention, the doctor may adjust the existing antihypertensive program or add new antihypertensive drugs to ensure that the blood pressure reaches the target.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

3. Risk of infection

(1) Performance: Corticosteroids will suppress the function of the immune system, which may increase the risk of infection, including common respiratory infections or rarer opportunistic infections.

(2) Mitigation measures: Try to avoid going to public places with dense crowds and poor ventilation. If you must go, please wear a high-protection mask correctly. Keep a safe distance from anyone who has a cold, flu, or other contagious illness.

Be highly alert to any possible symptoms of infection, such as fever, chills, persistent cough, sore throat, painful urination, or red, swollen, hot and painful wounds, etc. If the above typical symptoms appear, you should seek medical treatment in time.

4. Mood swings and sleep disorders

(1) Performance: Mood swings, anxiety, insomnia and even euphoria may occur.

(2) Mitigation measures: Try to maintain a fixed schedule, go to bed and get up at the same time every day, and create a dark, quiet, and cool sleeping environment. Avoid using electronic devices such as mobile phones and computers one hour before going to bed. The blue light they emit will inhibit melatonin secretion and interfere with sleep.

If emotional problems exist for a long time or have a great impact on daily life, you should seek professional help in time, and they can be effectively dealt with and solved through professional psychological consultation or treatment.

In some cases, your doctor may consider short-term use of a sleep aid or adjusting the dose of budesonide extended-release capsules.

Some side effects of budesonide extended-release capsules usually do not require medical intervention and may disappear during treatment as the body gradually adapts to the drug. However, if the side effects persist, are bothersome, or if you have any questions, please consult a medical professional in time.