他泽司他可以治疗哪些病症？常见的副作用有哪些？

The FDA accelerated approval of a new drug in January 2020, which has attracted the attention of many patients. The drug is the first and only approved EZH2 inhibitor. It is an inhibitor of histone lysine methyltransferase EZH2 and inhibits the transcriptional activity of tumor suppressor genes. Today let’s take a closer look at what diseases tazerestat can treat? What are the common side effects?

The currently approved indications of tazerestat are mainly for the treatment of adult and pediatric patients 16 years and older with metastatic or locally advanced epithelioid sarcoma who are not suitable for complete resection; and adult patients with relapsed or refractory follicular lymphoma. Tazerestat is the first treatment option specifically for epithelioid sarcoma, a rare soft tissue sarcoma. Eisai announced that the Japanese Ministry of Health, Labor and Welfare (MHLW) has approved tazerestat for the treatment of patients with relapsed or refractory EZH2 gene mutation-positive follicular lymphoma (FL) on June 24, 2021. The drug is limited to use when standard treatments are not applicable. Tazetostat is the first approved epigenetic drug for sarcoma and represents a novel treatment approach, particularly for patients with advanced or metastatic epithelioid sarcoma who are not candidates for curative surgery.

So, what are the common side effects of tazerestat?

It varies according to different indications. Musculoskeletal pain, fatigue, upper respiratory tract infection, nausea and abdominal pain are common side effects of this drug in the treatment of follicular lymphoma patients, while decreased appetite, pain, fatigue, nausea, vomiting and constipation are the most common side effects of the drug in the treatment of epithelioid sarcoma patients. Patients should pay attention to their own reactions during medication, and if they develop intolerance, contact their doctor promptly and adopt a new treatment plan. Overall, the safety profile of tazerestat is controllable.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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