2025年Cobenfy(KarXT)最新价格是多少钱一盒？

Cobenfy (KarXT) is an innovative drug. Its price information is not yet clear and needs to be inquired through official channels or pharmacies.

How much is the latest price of Cobenfy (KarXT) per box in 2025?

The latest price in 2025 has not yet been determined. If you need to obtain the price, you can consult a medical service institution, or go to a hospital pharmacy in the country where Cobenfy is listed or get the specific price information in the pharmacy.

Cobenfy (KarXT) Pharmacokinetics

1. Absorption and food effects

(1) Absorption speed: After taking it, zetanolmeline reaches the peak blood concentration in about 2 hours, while trospium chloride can reach it in about 1 hour.

(2) Key food effects: Food, especially high-fat food, will significantly reduce the absorption of trospium chloride. Compared with the fasting state, a high-fat meal can reduce the peak plasma concentration and total exposure of trospium chloride by 70%-75% and 85%-90% respectively. Therefore, to ensure the effectiveness of the drug, Cobenfy must be taken on an empty stomach, that is, at least 1 hour before or 2 hours after a meal.

2. Distribution

After the drug enters the body, it will be extensively combined with plasma proteins. The protein binding rate of xanomeline is about 95% and that of trospium chloride is about 80%. This high binding rate may affect the free concentrations of other drugs, but the clinical significance is unclear.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

3. Metabolism and excretion

(1) Metabolism: Xanomeline is mainly metabolized by the CYP2D6 enzyme in the liver, while trospium chloride is rarely metabolized and is mainly excreted in its original form.

(2) Excretion and elimination: The elimination of trospium chloride mainly depends on the kidneys, and is excreted unchanged in the urine through active renal tubular secretion (about 85%-90%). This makes it possible to interact with drugs that are also excreted through this route (such as metformin), and the exposure in patients with moderate to severe renal insufficiency will be significantly increased. Xanomeline is mainly eliminated through metabolism, with only a very small amount of unchanged form excreted in the urine.

4. Pharmacokinetics in special populations

(1) Patients with renal insufficiency: Moderate to severe renal impairment (eGFR<60mL/min) will lead to a significant increase in the exposure of the two components, especially trospium chloride, and increase the risk of anticholinergic adverse reactions, so it is not recommended for use in this group of people.

(2) Patients with hepatic insufficiency: Hepatic impairment will significantly increase the exposure of Zetanrol. This product is contraindicated in patients with moderate to severe liver disease, and is not recommended for patients with mild liver disease.

How to store Cobenfy (KarXT) correctly

1. Storage temperature

Cobenfy should be stored at room temperature between 20°C and 25°C (68°F and 77°F). Fluctuations between 15°C and 30°C (59°F and 86°F) are allowed for short periods of time.

2. Dosage form and operation

Cobenfy is in capsule form. Please be sure to swallow the capsule whole and do not open, chew or crush the capsule to avoid affecting the release behavior of the drug in the body and possibly increasing gastrointestinal adverse reactions.

3. Safety precautions

Please keep medicines out of the reach and sight of children to avoid accidental ingestion, and do not use medicines that have expired.